- A facile synthesis of 3,5,7-trisubstituted-4H-[1,2]diazepines by microwave irradiation
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A novel approach for the synthesis of 3,5,7-trisubstituted-4H-[1,2] diazepine 5a-p from α,β-unsaturated 1,5-diketone 4 by the condensation of substituted acetophenones 1 with 1,3-dicarbonyl compound 3 in the presence of sodium tertiary butoxide has been described. The intermediate 4 reacts smoothly with hydrazine hydrate catalysed by PSSA in water under microwave irradiation to yield the product 5.
- Manih, Rudolf Manton,Myrboh, Bekington
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p. 1613 - 1618
(2013/01/15)
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- Electron impact Mass Spectra of 3,5,7-Triaryl- and -Trialkyl-4H-1,2-Diazepines
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Electron impact mass spectra of 3,5,7-trisubstituted 4H-1,2-diazepines indicate that aryl substituents lead to N2 expulsion while alkyl substituents do not.A common fragmentation pattern is observed and discussed for all alkyldiazepines, most of which are newly reported compounds.Assignments are based on electron impact mass spectra of deuteriated substrates and high resolution mass spectra.A previous interpretation of N2 expulsion is corrected.
- Balaban, Alexandru T.,Gheorghiu, Mircea D.,Balaban, Teodor Silviu
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p. 433 - 437
(2007/10/02)
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