OPIOID HAPTENS, CONJUGATES, VACCINES, AND METHODS OF GENERATING ANTIBODIES
The disclosure provides, inter alia, opioid haptens, opioid hapten conjugates, opioid vaccines, methods of treating or preventing opioid use disorder, methods of treating opioid overdose, and methods of generating and/or isolating antibodies selective for opioids.
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Paragraph 0259-0260
(2020/02/14)
RECEPTOR REGULATOR
A compound having a partial structure represented by the formula (A) (wherein ring Xa represents a nitrogen-containing ring and R represents optionally substituted amino) or a salt thereof. The compound or salt is highly effective in regulating neuromedin U receptors and is useful as a preventive/therapeutic agent for hypertension, etc.
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Page/Page column 37
(2010/02/13)
A convenient method for the N-acylation and esterification of hindered amino acids: Synthesis of ultra short acting opioid agonist, remifentanil
A general method has been devised for the one step preparation of N- acylamino acid esters of type 7 from the corresponding a-amino acids in high yield under mild conditions and a probable mechanism is proposed.
Coleman, Mark J.,Goodyear, Michael D.,Latham, David W. S.,Whitehead, Andrew J.
p. 1923 - 1924
(2007/10/03)
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