- Preparation method of zolpidem
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The invention belongs to the field of pharmacy, and relates to a method for preparing zolpidem. The preparation method comprises the following steps: taking maleic anhydride and 2-amino-4-methylpyridine as raw materials, and carrying out a series of react
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- Rhodium catalyzed direct C3-ethoxycarbonylmethylation of imidazo[1,2-a]pyridines with ethyl diazoacetate
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An efficient and environment-friendly C3-ethoxycarbonylmethylation of imidazo[1,2-a]pyridines with ethyl diazoacetate in the presence of a Rh(II) catalyst was developed. Such strategy not only enables the synthesis of zolpidem, but also provides a way to
- Dong, Hui,Hu, Wenhao,Huang, Qiuyao,Li, Bingbing,Wang, Yuanxiang
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supporting information
(2020/02/13)
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- Practical and scalable preparation of Minodronic acid and Zolpidem from 2-chloroimidazole[1,2-a]pyridines
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Practical and scalable procedures for Minodronic acid and Zolpidem are developed with short reaction sequences from 2-aminopyridines and maleic anhydride, respectively. The new procedures avoid column chromatography for the purification in all synthetic steps. Key aspects of this development involve reductive hydrodechlorination and Suzuki coupling reaction of 2-chloroimidazole[1,2-a]pyridines, and their application towards synthesis of the two drugs is also addressed.
- Wang, Yuheng,Zhang, Bingbing,Zheng, Yinying,Ma, Qiaoning,Sui, Qiang,Lei, Xinsheng
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p. 1064 - 1071
(2019/01/14)
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- Imidazo[1,2-a]pyridin-3-yl-acetic acid hydrazides, processes for their preparation and pharmaceutical uses thereof
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The invention provides novel imidazo[1,2-a]pyridin-3-yl-acetic acid hydrazides of formula (I) wherein R1, R2 and R3 have different meanings, and pharmaceutically acceptable salts, polymorphs, hydrates, tautomers, solvates and stereoisomers thereof. Compou
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Page/Page column 9-10
(2008/06/13)
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