An efficient means for generating p-methoxybenzyl (PMB) ethers under mildly acidic conditions
The protection of a wide variety of alcohols as their p-methoxybenzyl ethers can be performed with PMBO-lepidine in the presence of methyl tosylate or, preferably, camphorsulfonic acid. No inorganic promoters are required, thereby facilitating workup and product isolation. Georg Thieme Verlag Stuttgart.
Stewart, Catherine A.,Peng, Xiaowen,Paquette, Leo A.
p. 433 - 437
(2008/09/20)
Synthesis of para-methoxybenzyl (PMB) ethers under neutral conditions
2-(4-Methoxybenzyloxy)-4-methylquinoline reacts with methyl triflate in the presence of alcohols to generate a neutral organic salt that transfers the para-methoxybenzyl (PMB) protecting group onto alcohols in high yield and under mild conditions. The Royal Society of Chemistry.
Nwoye, Ernest O.,Dudley, Gregory B.
p. 1436 - 1437
(2008/02/02)
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