cas 258506-68-2, 3-Chloro-6-trifluoromethyl-pyridazine

Articles about 258506-68-2Total 14 be found

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COMPOUNDS AND COMPOSITIONS FOR USE IN TREATING SKIN DISORDERS
Provided herein is a compound of formula (XXXII) or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer thereof or a physiologically functional derivative thereof, wherein R1, R2, R3, G, A, E, n, p, and q are defined herein. Also provided herein are compositions comprising a compound of formula (XXXII), and methods of using a compound of formula (XXXII), e.g., in the treatment or prevention of skin disorders.
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Paragraph 1849; 1852-1853

(2021/08/06)

CYCLOPROPANE DERIVATIVE AND DRUG CONTAINING SAME
A compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a pharmaceutically acceptable salt thereof has superior TRPA1 antagonist activity, and the compound or a pharmaceutically acceptable salt thereof is useful for the prophylaxis or treatment of diseases involving TRPA1 antagonist and TRPA1.
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Paragraph 0143

(2018/06/15)

PESTICIDALLY ACTIVE TETRACYCLIC HETEROCYCLIC DERIVATIVES WITH SULPHUR CONTAINING SUBSTITUENTS
Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.
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Page/Page column 55

(2016/05/24)

PESTICIDALLY ACTIVE POLYCYCLIC DERIVATIVES WITH SULFUR SUBSTITUTED FIVE-MEMBERED RING HETEROCYLES
Polycyclic derivatives of formula (I) wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.
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Page/Page column 85; 86

(2016/11/14)

PESTICIDALLY ACTIVE POLYCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS
Polycyclic derivatives of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.
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Page/Page column 89; 90

(2016/12/22)

HETEROCYCLIC SULFONAMIDE DERIVATIVE AND MEDICINE COMPRISING SAME
The present invention provides a compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a pharmaceutically acceptable salt thereof. The compound has a superior TRPA1 antagonist activity, and can provide a medicament useful for the prophylaxis or treatment of diseases involving TRPA1 antagonist and TRPA1.
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Paragraph 0548; 0549; 0550

(2016/12/01)

CONDENSED HETEROCYCLIC COMPOUND OR SALT THEREOF, AGRICULTURAL AND HORTICULTURAL INSECTICIDE COMPRISING THE COMPOUND, AND METHOD FOR USING THE INSECTICIDE
An object of the present invention is to provide and develop novel agricultural and horticultural insecticides in view of the still immense damage caused by insect pests etc. and the emergence of insect pests resistant to existing insecticides in crop production in the fields of agriculture, horticulture and the like. Provided are a condensed heterocyclic compound represented by the general formula (I): {wherein A1, A2 and A3 may be the same or different, and each represent a nitrogen atom or a CH group, R1 represents an alkyl group or the like, R2 represents a haloalkyl group or the like, R3 represents a hydrogen atom or the like, R4 represents a haloalkyl group or the like, R5 represents an alkyl group or the like, and m represents 0 or 2} or a salt thereof; an agricultural and horticultural insecticide comprising the compound or a salt thereof as an active ingredient; and a method for using the insecticide.
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Paragraph 0163-0165

(2016/02/16)

PEST CONTROL AGENT COMPOSITION CONTAINING IMIDAZOPYRIDAZINE DERIVATIVE AND APPLICATION METHOD THEREFOR
PROBLEM TO BE SOLVED: To provide a novel technology for efficiently controlling pests difficult to control or impossible to control with conventional technologies. SOLUTION: There is provided a pest control agent composition by combining an imidazopyridazine derivative represented by the general formula (I) (where A1, A2 and A3 represent a CH group or a N group, R1 represents an alkyl group or the like, R2 represents a haloalkyl group, R3 represents a hydrogen atom or the like, R4 represents a haloalkyl group or the like, R5 represents an alkyl group or the like, and m is 0 or 2) or salts thereof and one or more compound selected from a group (B). The (B) group is pyrifluquinazon, tiadinil or the like. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT
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Paragraph 0174; 0175

(2016/10/08)

Copper-mediated trifluoromethylation of heteroaromatic compounds by trifluoromethyl sulfonium salts
Copper is king! A convenient method for the synthesis of trifluoromethylated heteroaromatic compounds under mild conditions has been developed based on the observation that 1 can be reduced by certain metals (see scheme). Substrate 1 is assumed to be reduced by copper via a single-electron transfer mechanism, and CuCF3 is the most probable intermediate in this reaction. DMF=N,N-dimethylformamide, Tf=triflate.
Zhang, Cheng-Pan,Wang, Zong-Ling,Chen, Qing-Yun,Zhang, Chun-Tao,Gu, Yu-Cheng,Xiao, Ji-Chang
supporting information; experimental part
p. 1896 - 1900
(2011/04/16)

Concise synthesis of ω-fluoroalkylated ketoesters. A building block for the synthesis of six-, seven-, and eight-membered fluoroalkyl substituted 1,2-diaza-3-one heterocycles
A concise and general synthetic route toward the small and medium-sized fluoroalkyl substituted 1,2-diaza-3-one heterocyclic ring skeletons via a sequential reaction of condensation and ring-closure reaction of ω-fluoroalkylated ketoesters 4 with hydrazin
Wan, Wen,Hou, Jie,Jiang, Haizhen,Wang, Yangli,Zhu, Shizheng,Deng, Hongmei,Hao, Jian
experimental part
p. 4212 - 4219
(2009/09/30)

Aryl sulfonamide and sulfonyl compounds as modulators of PPAR and methods of treating metabolic disorders
Aryl sulfonamide and sulfonyl compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
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Page/Page column 66

(2010/02/14)

SUBSTITUTED NITROGEN-CONTAINING SIX-MEMBERED AMINO-HETEROCYCLES AS VANILLOID-1 RECEPTOR ANTAGONISTS FOR TREATING PAIN
The present invention provides a compound of formula (I): Y-J-NH-Z wherein: Y is a quinoline or isoquinoline optionally substituted with one or two substituents independently chosen from hydroxy, halogen, haloC1-4alkyl, C1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, nitro and amino; J is pyridine, pyridazine, pyrazine, pyrimidine or triazine optionally substituted with one or two substituents independently chosen from hydroxy, halogen, haloC1-4alkyl, C1-4alkyl, C3-5cycloalkyl, C1-4alkoxy, hydroxyC1-4alkyl, cyano, hydroxy, C1-4cycloalkoxy, C1-4alkylthio, haloC1-4alkoxy, nitro, Q, (CH2)pQ, NR2R3, -(CH2)pNR2R3 and -O(CH2)pNR2R3; wherein J is substituted at positions meta to each other by NH and Y; and Z is phenyl or pyridyl optionally substituted with one or two substituents independently selected from halogen, haloC1-4alkyl, C1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, nitro and amino; Q is phenyl, a five-membered heterocyclic ring containing one, two, three or four heteroatoms chosen from O, N and S, at most one heteroatom being O or S, or a six-membered heterocyclic ring containing one, two or three nitrogen atoms, optionally substituted by C1-4alkyl; each R2 and R3 is chosen from H and C1-4alkyl, or R2 and R3, together with the nitrogen atom to which they are attached, may form a six-membered ring optionally containing an oxygen atom or a further nitrogen atom, which ring is optionally substituted by C1-4alkyl or Q; p is 1, 2 or 3; or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising it; its use in methods of therapy; use of it for manufacturing medicaments; and methods of using it to treat diseases requiring administration of a VR1 antagonist such as pain, cough, GERD and depression.
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Page/Page column 49

(2010/02/11)

1,2-AZOLE DERIVATIVES WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY
A compound represented by the formula (1) wherein ring A is a ring optionally having 1 to 3 substituents; ring B is a 1,2-azole ring which may further have 1 to 3 substituents; Xa, Xb and Xc are the same or different and each is a bond, - O -, - S - and the like; Ya is a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; Yb and Yc are the same or different and each is a bond or a divalent aliphatic hydrocarbon residue having 1 to 20 carbon atoms; ring C is a monocyclic aromatic ring which may further have 1 to 3 substituents; and R represents -OR4 (R4 is hydrogen atom or optionally substituted hydrocarbon group) and the like, or a salt thereof or a prodrug thereof is useful as an agent for the prophylaxis or treatment of diabetes and the like.
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(2010/02/05)

Desymmetrization of dichloroazaheterocycles
3,6-Dichloropyridizine 1a was converted in good yield into its mono-iodo derivative 1b when treated with a mixture of hydriodic acid and sodium iodide. Pure samples of the mono-iodo derivatives 2b, 3b and 4b could not be obtained from their corresponding dichlorinated precursors with these reagents. Compounds 1b and 4b underwent palladium catalysed Suzuki, Sonogashira and other coupling reactions.
Goodman, Allan J.,Stanforth, Stephen P.,Tarbit, Brian
p. 15067 - 15070
(2007/10/03)

Chemical Properties

Melting Point: 55-59°C
Boiling Point: 233.343 °C at 760 mmHg
Flash Point:94.923 °C
Density: 1.504 g/cm³
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Vapor Pressure: 0.086mmHg at 25°C
Refractive Index: 1.445
PKA: -1.53±0.10(Predicted)
PSA: 25.78000
LogP: 2.14880

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258506-68-2

Articles about 258506-68-2Total 14 be found

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Chemical Properties

Melting Point: 55-59°C

Boiling Point: 233.343 °C at 760 mmHg

Flash Point:94.923 °C

Density: 1.504 g/cm³

Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C

Vapor Pressure: 0.086mmHg at 25°C

Refractive Index: 1.445

PKA: -1.53±0.10(Predicted)

PSA: 25.78000

LogP: 2.14880

Global suppliers and manufacturers of 258506-68-2total 78 suppliers on LookChem

Article Database

258506-68-2

Articles about 258506-68-2Total 14 be found

More Articles about upstream products of 258506-68-2

Chemical Properties

Melting Point: 55-59°C

Boiling Point: 233.343 °C at 760 mmHg

Flash Point:94.923 °C

Density: 1.504 g/cm3

Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C

Vapor Pressure: 0.086mmHg at 25°C

Refractive Index: 1.445

PKA: -1.53±0.10(Predicted)

PSA: 25.78000

LogP: 2.14880

Global suppliers and manufacturers of 258506-68-2total 78 suppliers on LookChem

Density: 1.504 g/cm³