cas 25939-05-3, N-(2,4,6-Trichlorophenyl)benzenecarbohydrazonoylchloride | Articles data ｜lookchem

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25939-05-3

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Synthesis and biological activity of anthelmintic thiadiazoles using an AF-2 receptor binding assay
Following our discovery of the strong binding of thiadiazole 1 to the AF-2 neuropeptide receptor of gastrointestinal nematodes (e.g., Ascaris suum), we prepared two series of analogs. Only the series containing the thiadiazole ring had potencies comparable to that of compound 1. Analog 50 exhibited an apparent potency in the AF-2 binding assay 300 times that of compound 1.
Lee, Byung H.,Dutton, Fred E.,Clothier, Michael F.,Bowman, Jerry W.,Davis, John P.,Johnson, Sandra S.,Thomas, Eileen M.,Zantello, Marjorie R.,Zinser, Erich W.,McGuire, James C.,Thompson, David P.,Geary, Timothy G.
p. 1727 - 1732
(2007/10/03)

Method of use, composition, and compounds
Certain benzoyl chloride phenylhydrazones have been found to be active against insects and mites. The benzoyl ring and the phenylhydrazone ring can be substituted with a halogen atom, a nitro group, or an alkyl group of from 1 to 6 carbon atoms, inclusive
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(2008/06/13)

Anthelmintic methods employing benzoyl chloride phenylhydrazones
Certain benzoyl chloride phenylhydrazones have been found to be active against insects and mites, and they have also been found to be effective, broad-spectrum anthelmintics for suppressing parasitic worms in animals, particularly sheep. The benzoyl ring
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(2008/06/13)

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Chemical Properties

Melting Point: 98°C
Boiling Point: 410.5°Cat760mmHg
Flash Point:202.1°C
Density: 1.44g/cm³
Vapor Pressure: 5.99E-07mmHg at 25°C
Refractive Index: 1.6000 (estimate)
PSA: 24.39000
LogP: 5.73230

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