- Comparative action of carbocyclic thromboxane A2 stereoisomers on platelets
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Stereospecific requirements for the interaction of the thromboxane A2 carbocyclic mimetic CTA2 1 with the human platelet PGH2/TXA2 receptor have been explored. The two pairs of trans-1,2 and cis-3,4 side chain diastereoisomers were synthesised and evaluated for agonist and antagonist activity in human platelet rich plasma. Interestingly, the natural and unnatural trans diastereoisomers, both possessed potent aggregatory activity and equipotently inhibited platelet responses to subsequent addition of agonists, whereas, the respective unnatural cis isomers proved only weakly active or inert.
- Caton, Michael P.L.,Stuttle, Keith A.J.,Tuffin, David P.,Ansell, Martin F.
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