- Process for the preparation of amine oxides
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The present invention provides a process for the preparation of amine oxide by reacting a tertiary or a secondary amine with hydrogen peroxide as an oxidant in the presence of a recyclable heterogeneous catalyst comprising a layered double hydroxide exchanged with an anion in the presence of an additive selected from the group consisting of benzonitrile, propionitrile, isoburyronitrile, benzamide and isobutyramide.
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Page/Page column 7
(2008/06/13)
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- The first example of catalytic N-oxidation of tertiary amines by tungstate-exchanged Mg-Al layered double hydroxide in water: A green protocol
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A green process, using a recyclable tungstate-exchanged Mg-A1 layered double hydroxide (LDH-WO42-) heterogenised catalyst and aqueous H2O2 oxidant in water, leads to N-oxidation of aliphatic tert-amines to amine N-oxides in quantitative yields, at a high rate at room temperature.
- Choudary,Bharathi,Venkat Reddy,Lakshmi Kantam,Raghavan
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p. 1736 - 1737
(2007/10/03)
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- Surface-Mediated Reactions. 9. Selective Oxidation of Primary and Secondary Amines to Hydroxylamines
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OXONE over silica gel or, in some cases, alumina has been found to oxidize the primary and secondary amines 3 selectively to the corresponding hydroxylamines 4, in either the presence or absence of a solvent. Treatment of Boc-protected L-lysine (6) under the latter conditions afforded hydroxylamine 7 in excellent yield. The trialkylamine 1a and pyridine (1b), in which selectivity is not an issue, were readily oxidized to the corresponding oxides 2 by OXONE over silica gel or alumina, as well as by (CH3)3COOH over silica gel. Solvent-free oxidation assisted by microwave irradiation was more forcing, while still affording the hydroxylamines 4 selectively, and is the synthetic method of choice. The mechanistic aspects of these reactions are discussed.
- Fields, John D.,Kropp, Paul J.
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p. 5937 - 5941
(2007/10/03)
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- Use of amine oxide in the H2 O2 oxidation of aliphatic mercaptan to sulfonic acid
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Hydrocarbyl mercaptans are oxidized to sulfonic acids by reaction with aqueous hydrogen peroxide in the presence of an inorganic base (e.g. sodium hydroxide) and a tert-amine oxide. The product is in the form of a sulfonate salt. The reaction rate is increased and undesirable free-oil by-product is decreased by the inclusion of the amine oxide catalyst.
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- AMINE OXIDES-XIII IODINE COMPLEXES WITH NON-AROMATIC AMINE OXIDES
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EDA-iodine complex with trialkylamine oxides in dichloromethane have been investigated spectrophotometrically.Thermodynamic (KADc,-ΔG0) and spectral (ΕADλ) characteristics of these complexes were determined.The absorption band of iodine in the visible region was blue-shifted with a variable maximum, depending on the structure of the amine oxide.The KADc and ΕADλ values were calculated using a modified method.A non-linear relationship KADc=(R), where R is the number of carbon atoms in the alkyl chain, was found.
- Devinsky, F.,Leitmanova, A.,Lacko, I.,Krasnec, L.
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p. 5707 - 5710
(2007/10/02)
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- Topical medicament preparations
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Topical therapeutic compositions are disclosed which contain from about 0.1 to 70 percent by weight of a water-soluble tertiary amine oxide and a therapeutic agent selected from the group consisting of erythromycin, benzoyl peroxide, hydrocortisone, tetracycline, 5-fluorouracil, and propranolol. The amine oxide enhances penetration of the therapeutic agent into and through the skin.
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