- Efficient Synthesis of Quinazolines from Aryl Imidates and N-Alkoxyamide by Ir(III)-Catalyzed C?H Amidation/Cyclization
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An Ir(III) catalyst was used for the first time to realize the synthesis of quinazolines by C?H bond activation/cyclization with N-alkoxyamides as amidation reagents. This reaction has the advantages of wide substrate adaptability, good to excellent yield
- Fan, Wei-Tai,Huang, Zhibin,Xu, Xu,Tu, Guangliang,Geng, Jingyao,Ji, Shun-Jun,Zhao, Yingsheng
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supporting information
p. 4144 - 4147
(2021/08/24)
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- ACID ALKYLATING AGENT, METHOD FOR GENERATING ACID ALKYLATION PRODUCT, RESIN COMPOSITION AND POLYESTER FILM
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PROBLEM TO BE SOLVED: To provide: an acid alkylating agent which causes less generation of irritant gas and suppresses generation of a gel component; a method for generating an acid alkylation product; a resin composition; and a polyester film. SOLUTION: There are provided: an acid alkylation agent represented by the following general formula (1) obtained by subjecting a compound having at least one acidic group selected from a carboxylic acid group, a sulfonic acid group, a phosphate group and a phenolic hydroxyl group to acid alkylation; a method for generating an acid alkylation product; a resin composition; and a polyester film. Q represents a group for bonding with a -C=N- site to form a 5 to 12- membered nitrogen-containing heterocycle; R11 to R13 each independently represents a hydrogen atom, an alkyl group or an aryl group; and R11 to R13 may be bonded each other to form a ring. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT
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Paragraph 0094-0095
(2017/02/24)
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- Overcoming the Limitations of C?H Activation with Strongly Coordinating N-Heterocycles by Cobalt Catalysis
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Strongly coordinating nitrogen heterocycles, including pyrimidines, oxazolines, pyrazoles, and pyridines, were fully tolerated in cobalt-catalyzed C?H amidations by imidate assistance. Structurally complex quinazolines are thus accessible in a step-economic manner. Our findings also establish the relative powers of directing groups in cobalt(III)-catalyzed C?H functionalization for the first time.
- Wang, Hui,Lorion, Mélanie M.,Ackermann, Lutz
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supporting information
p. 10386 - 10390
(2016/08/24)
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- Quinazoline synthesis via Rh(III)-catalyzed intermolecular C-H functionalization of benzimidates with dioxazolones
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An efficient double C-N bond formation sequence to prepare highly substituted quinazolines utilizing benzimidates and dioxazolones under the catalytic redox-neutral [Cp?RhCl2]2/AgBF4 system, where dioxazolones could work as an intern
- Wang, Jie,Zha, Shanke,Chen, Kehao,Zhang, Feifei,Song, Chao,Zhu, Jin
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supporting information
p. 2062 - 2065
(2016/06/06)
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- Co(III)-Catalyzed Synthesis of Quinazolines via C-H Activation of N-Sulfinylimines and Benzimidates
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C-H activation of arenes has been established as an important strategy for heterocycle synthesis via annulations between arenes and unsaturated coupling partners. However, nitriles failed to act as such a coupling partner. Dioxazolones have been employed as a synthon of nitriles, and subsequent coupling with arenes such as N-sulfinylimines and benzimidates bearing a functionalizable directing group provided facile access to two classes of quinazolines under Co(III)-catalysis.
- Wang, Fen,Wang, He,Wang, Qiang,Yu, Songjie,Li, Xingwei
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supporting information
p. 1306 - 1309
(2016/04/01)
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- Thermal ring contraction of 3H-1,4-benzo- diazepines into quinazolines
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The thermolysis of the 5-methoxy-(11a-c) and 5-diethylamino-3H-1,4- benzodiazepines (14a-c) resulted in a ring transformation to give the 4- methoxy-(12a-c) and 4-diethylaminoquinazolines (15a-c), respectively. The mechanism of this ring contraction is also described.
- Kaname, Mamoru,Tsuchiya, Takashi,Sashida, Haruki
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p. 2407 - 2413
(2007/10/03)
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- RING OPENING OF 4-CHLOROQUINAZOLINE INTO 2-ARYLMETHYLENEAMINOBENZONITRILE BY GRIGNARD REACTION
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The treatment of 4-chloroquinazoline (1) with arylmagnesium bromide (3) in tetrahydrofuran (THF) resulted in the formation of 2-arylmethyleneaminobenzonitrile (2).Continued reaction of ring opening of 1 and subsequent hydrolysis of the products (2) afforded the corresponding arenecarbaldehydes (4).
- Miyashita, Akira,Sasaki, Takami,Oishi, Etsuo,Higashino, Takeo
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p. 823 - 832
(2007/10/02)
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- HAMMETT-TAFT CONSTANTS OF SUBSTITUTED 2- AND 4-QUINAZOLINYL GROUPS
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From the chemical shifts of the meta- and para-carbon atoms of the phenyl group in phenylquinazolines the ?I and ?R0 constants of 2- and 4-quinazolinyl groups were determined.Correlation equations which enable us to calcul
- Baram, S. G.,Shkurko, O. P.,Mamaev, V. P.
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p. 601 - 605
(2007/10/02)
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