- Synthesis and Structure of 1-Substituted Semithioglycolurils
-
Two methods for the synthesis of previously unavailable 1-substituted semithioglycolurils were developed. These methods consist of the cyclocondensation of 1-substituted ureas with 4,5-dihydroxy- or 4,5-dimethoxyimidazolidine-2-thione or glyoxal, followed by the reaction of the resulting 1-substituted 4,5-dihydroxyimidazolidine-2-ones with HSCN in a two-step one-pot procedure. Two of the desired semithioglycolurils were obtained as conglomerates.
- Baranov, Vladimir V.,Galochkin, Anton A.,Kravchenko, Angelina N.,Makhova, Nina N.,Nelyubina, Yulia V.
-
p. 2563 - 2571
(2020/09/07)
-
- Chemical modulators of heat shock protein 70 (Hsp70) by sequential, microwave-accelerated reactions on solid phase
-
Molecular chaperones, such as Hsp70 and Hsp90, are responsible for a variety of protective, anti-apoptotic functions. While inhibitors of Hsp90, such as geldanamycin and its derivative 17-AAG, are well known and important anti-cancer leads, Hsp70 has rece
- Wisen, Susanne,Androsavich, John,Evans, Christopher G.,Chang, Lyra,Gestwicki, Jason E.
-
-
- Synthesis of 2-monofunctionalized 2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7- diones
-
New (1R*,5S*)-2-R-2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7- diones containing the terminal carboxy or hydroxy group in the substituent R were synthesized by cyclocondensation of 4,5-dihydroxyimidazolidin-2-one with 1-R-ureas. Single-crystal X-ray diffraction analysis showed that 2-carboxyethyl-2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7-dione crystallizes as a racemate.
- Kravchenko,Maksareva,Belyakov,Sigachev,Chegaev,Lyssenko,Lebedev,Makhova
-
p. 192 - 197
(2007/10/03)
-
- ISOLATION AND STRUCTURES OF NEW UREIDO AMINO ACIDS, LIVIDINE AND GRATELOUPINE, FROM RED ALGAE GRATELOUPIA C. AGARDH GENUS
-
Two new ureido amino acids, lividine (1) and grateloupine (2) , were isolated from Grateloupia livida and Grateloupia filicina respectively.The structures of both amino acids were assumed mainly by NMR spectra and determined as Nω-carbamoyl-L-c
- Wakamiya, T.,Kobayashi, Y.,Shiba, T.,Setogawa, K.,Matsutani, H.
-
p. 235 - 240
(2007/10/02)
-
- 1,3-Diazepinones. 2. The Correct Structure of Squamolone as 1-Carbamoyl-2-pyrrolidinone and Synthesis of Authentic Perhydro-1,3-diazepine-2,4-dione
-
The natural product squamolone,previously reported as 4-oxoperhydro-1,3-diazepin-2-one (1), was found to be instead 1-carbamoyl-2-pyrrolidinone (2).An unequivocal synthesis of the diazepinedione 1 starting from glutaric acid monoamide (6) produced the desired compound in five steps.Diborane reduction of 1 yielded the known perhydro-1,3-diazepin-2-one (10, tetramethyleneurea), confirming the seven-membered-ring structure of 1.A detailed analysis of the IR, NMR, and mass spectra of squamolone (2) and its isomer 1 is presented.A one-step synthesis of squamolone (2) starting with 4-aminobutyric acid 3 is reported.
- Marquez, Victor E.,Kelley, James A.,Driscoll, John S.
-
p. 5308 - 5312
(2007/10/02)
-