- Ni-Catalyzed enantioselective reductive arylcyanation/cyclization of: N -(2-iodo-aryl) acrylamide
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A Ni/(S,S)-BDPP-catalyzed intramolecular Heck cyclization of N-(2-iodo-aryl) acrylamide with 2-methyl-2-phenylmalononitrile was developed to give oxindoles with good enantioselectivities. We found that utilizing such an electrophilic cyanation reagent cou
- Dong, Kaiwu,Ren, Xinyi,Shen, Chaoren,Wang, Guangzhu
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p. 1135 - 1138
(2022/02/03)
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- Kinetics and Mechanism of Oxidation of Carbenicillin by Copper (III) Periodate Complex in Aqueous Alkaline Medium
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Kinetics and mechanism of oxidation of carbenicillin by diperiodatocuprate [DPC-III] in aqueous alkaline medium were studied spectrophotometrically at 298 K and an ionic strength of 0.10 mol·dm-3. The reaction between DPC (III) and carbenicilli
- Mishra, Parashuram,Sahu, Yuv Raj
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- Pyrimidinium compound, and preparation method and application thereof
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The invention relates to a pyrimidinium compound, and a preparation method and an application thereof, and concretely relates to a pyrimidinium compound represented by formula (B2-A) or a stereoisomer, a nitrogen oxide and a salt thereof, an application of the above compounds as insecticides in agriculture, a form of an insecticide composition of the compound, and a method for controlling pests byusing the compounds or the composition. In the formula (B2-A), U, L, R, R, R, R, R, R, R, o and w have the meanings described in the invention.
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Paragraph 0031-0035
(2020/06/05)
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- Mesoionic insecticide
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The invention relates to a mesoionic compound. Specifically, the present invention relates to a mesoionic compound represented by formula (I) or a stereoisomer, a nitrogen oxide and a salt thereof ofthe mesoionic compound represented by formula (I), and a process for the preparation of mesoionic compounds, and their use as insecticides in agriculture, and their forms of insecticide compositions,as well as methods of controlling pests with these compounds or compositions; wherein R1, R2, R3, R4, R5, Ra, Rb, Rc, Rd, n, R6 and R7 have the meanings described in the invention.
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Paragraph 0173-0175
(2020/09/16)
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- Asymmetric Synthesis of α-Trifluoromethylthio-β-Amino Acids under Phase Transfer Catalysis
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The first asymmetric α-trifluoromethylthiolation of 2-substituted isoxazolidin-5-ones was developed using Maruoka type N-spiro ammonium catalysts under phase-transfer conditions. The resulting products, containing a trifluoromethylthiolated quaternary chiral carbon, were obtained in moderate to good yields and up to 98:2 enantiomeric ratio. Moreover, the easy N-O bond cleavage provided access to undescribed α-trifluoromethylthio-β2,2-amino acids, with promising applications in biochemistry and medicinal chemistry.
- Capaccio, Vito,Sicignano, Marina,Rodríguez, Ricardo I.,Della Sala, Giorgio,Alemán, José
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supporting information
p. 219 - 223
(2019/12/30)
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- Pyrimidine onium compound and application thereof
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The invention relates to a pyrimidine onium compound, nitride oxides, salt of the nitride oxides and a composition comprising the compound. The invention further relates to an application of the compound to plant pest control.
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Paragraph 0171; 0178-0179
(2019/10/23)
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- Exploring the Promiscuous Enzymatic Activation of Unnatural Polyketide Extender Units in Vitro and in Vivo for Monensin Biosynthesis
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The incorporation of new-to-nature extender units into polyketide synthesis is an important source for diversity yet is restricted by limited availability of suitably activated building blocks in vivo. We here describe a straightforward workflow for the biogenic activation of commercially available new-to-nature extender units. Firstly, the substrate scope of a highly flexible malonyl co-enzyme A synthetase from Streptomyces cinnamonensis was characterized. The results were matched by in vivo experiments in which the said extender units were accepted by both the polyketide synthase and the accessory enzymes of the monensin biosynthetic pathway. The experiments gave rise to a series of predictable monensin derivatives by the exploitation of the innate substrate promiscuity of an acyltransferase and downstream enzyme functions.
- Grote, Marius,Schulz, Frank
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p. 1183 - 1189
(2019/03/11)
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- Method for greenly synthesizing 5-hydroxy-5-alkyl disubstituted barbituric acid derivative by amine catalysis of air oxidation
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The invention relates to the field of oxidative synthesis, and in particular, relates to a 5-hydroxy-5-alkyl disubstituted barbituric acid derivative greenly synthesized by amine catalysis of air oxidation and a method thereof. The amine-catalyzed oxidation reaction of a 5-substituted 1,3-dimethylbarbituric acid derivative is studied; reaction catalysts and solvents are screened, hydroxylation ofalpha-C-H of 5-aryl or benzyl substituted barbituric acid compounds is found out to be realized through catalytic reaction under different conditions. The method has the following characteristics: (1)air is used as the source of hydroxyl functional groups, so the requirements of green development are met; (2) easily available and cheap alkali R3N rather than expensive metal catalysts is used; and(3) stoichiometric harmful phosphine compounds are prevented from being used as additives and reductants.
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- Cathode made of compacted silver nanoparticles for electrocatalytic carboxylation of 1-phenethyl bromide with CO2
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Silver nanoparticles prepared by the direct reduction of AgNO3 in aqueous solution were compacted into coins and used as the cathode for the electrocatalytic carboxylation of 1-phenethyl bromide with CO2. The influences of the working electrode, charge, current density and temperature were investigated. Under optimized conditions, 98% yield of 2-phenylpropionic acid was obtained. The reaction was performed under very mild conditions and no added catalyst was required in the electrolyte. Yields that varied from moderate to excellent were also achieved with other benzyl bromides. This electrode has good stability and reusability, and the yield and selectivity of 2-phenylpropionic acid could be maintained during reuse for 10 times.
- Yang, Hengpan,Wu, Laxia,Wang, Huan,Lu, Jiaxing
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p. 994 - 998
(2016/07/06)
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- Copper-catalyzed intermolecular chloro- and bromotrifluoromethylation of alkenes
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A highly practical copper-catalyzed intermolecular halotrifluoromethylation of alkenes has been developed under mild reaction conditions. A variety of Cl/Br-containing trifluoromethyl derivatives were directly synthesized from a wide range of alkenes, including electron-deficient and unactivated alkenes.
- Fu, Mingyang,Chen, Long,Jiang, Yongpeng,Jiang, Zhong-Xing,Yang, Zhigang
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supporting information
p. 348 - 351
(2016/02/19)
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- Total synthesis of monocyclic pyrimidinium betaines with fatty alkyl chains
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Seven betaines were prepared by condensation of N,N'-diphenylamidines with malonic acid derivatives. The amidines were made via a multistep synthesis, starting from their corresponding fatty acids. Malonyl chloride and dipentachlorophenyl phenylmalonate, two derivatives of malonic acid, were obtained from malonic acid and benzyl chloride, respectively. Most of the products were characterized by IR, UV, 1H and 13C NMR. Biological assays of the synthesized betaines revealed their good antibacterial and antifungal activities against the Pseudomonas aeruginosa, Bacillus subtilis and Mucor ramannianus and an activity against Candida albicans.
- Malki, Fatiha,Touati, Abdelkader,Rahal, Said,Moulay, Saad
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p. 961 - 967
(2011/12/21)
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- Catalytic asymmetric protonation of chiral calcium enolates via 1,4-addition of malonates
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Catalytic asymmetric protonation of chiral calcium enolates was performed. Chiral calcium enolates, prepared in situ from imides and malonates via 1,4-addition in the presence of catalytic amounts of Ca(OEt)2, Ph-PyBox, and achiral phenol, were smoothly protonated to afford adducts bearing tertiary asymmetric carbons in high yields with high enantioselectivities. The adducts were readily converted to optically active 2-substituted 1,5-dicarboxylic acid derivatives.
- Poisson, Thomas,Yamashita, Yasuhiro,Kobayashi, Shu
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supporting information; experimental part
p. 7890 - 7892
(2010/08/05)
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- Metalation of toluene and cumene with alkali metal-crown ether complexes
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Metalation of toluene and isopropylbenzene with alkali metal-crown ether complexes led to the corresponding α-metalated alkylbenzenes. Treatment of the latter in succession with solid carbon dioxide, water, and hydrochloric acid gave carboxylic or dicarboxylic acids in 65-78% yield. Metalation of isopropylbenzene with sodium or potassium crown ether complexes above 90°C was accompanied by cleavage of the polyether ring with formation of organometallic compounds which then reacted with isopropylbenzene to produce 2-sodio(potassio)-2-phenylpropane and open-chain oligoether.
- Shabanov,Seidov,Gasanova,Kakhramanova,Gasanova
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experimental part
p. 26 - 29
(2009/06/28)
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- ELECTROCHEMICAL CARBOXYLATION OF BENZAL CHLORIDE
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The electrocarboxylation of benzal chloride to α-chlorophenylacetic and phenylmalonic acids is realized in diaphragmless cells with aluminium sacrificial anodes.Yields respectively up to 50 percent and 30 percent can be obtained.Phenylacetic acid is always present among the products.
- Silvestri, G.,Gambino, S.,Filardo, G.,Greco, G.,Gulotta, A.
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p. 4307 - 4308
(2007/10/02)
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- 1,1-Alkanediol dicarboxylate linked antibacterial agents
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Useful antibacterial agents in which a penicillin and/or a beta-lactamase inhibitor are linked via 1,1-alkanediol dicarboxylates are of the formula STR1 where A is the residue of certain dicarboxyic acids, R3 is H or (C1 -C3), n is zero or 1 such that when n is zero R is P or B and R1 is the residue of certain esters, H or a salt thereof; and when n is 1, one of R and R1 is P and the other is B, and P is STR2 where R2 is H or certain acyl groups, and B is the residue of a beta-lactamase inhibiting carboxylic acid; a method for their use, pharmaceutical compositions thereof and intermediates useful in their production.
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- Process for N-acylation of 7 amino cephem compounds
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A compound having the formula: EQU1 and a 7-amihocephalosporanic acid derivative having the formula: SPC1 Are reacted in a homogeneous aqueous solution of the reactants to prepare a reaction of the formula: SPC2 In the formulas, R may be H or other defined substituents such as carboxyl group; R1 is H, an alkyl of 1-4 carbons or other defined substitents; R2 is H or phenyl or when taken together with R1 form a defined cyclicradical; R3 is H or other defined substituents and M is an alkali metal cation, ammonium cation or H.
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