- New methodology for the synthesis of 3-substituted coumarins via palladium-catalyzed site-selective cross-coupling reactions
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A particularly useful, easy, and concise synthesis of diversified 3-aryl coumarin was achieved using Heck coupling reactions between coumarin and aryliodides. The introduction of the aryl moiety occurred regioselective at the 3-position of the heteroaromatic ring. Georg Thieme Verlag Stuttgart - New YorK.
- Martins, Sérgio,Branco, Paula S.,Delatorre, María C.,Sierra, Miguel A.,Pereira, António
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supporting information; experimental part
p. 2918 - 2922
(2011/02/26)
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- Alpha,beta-unsaturated esters and acids by stereoselective dehydration
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There are provided by the present invention certain pyrazole based CCK-1 receptor modulators which have the general formula: wherein Ar is an aromatic or heteroaromatic group, X is a hydrocarbon linker, Y is a bond or hydrocarbon linker and R1, R2, R3, R4 and R5 are certain organic substituents, methods for making the same, and stereoselective dehydration methods for generally making α,β-unsaturated esters, acids and their derivatives.
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Page/Page column 107
(2010/02/15)
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- Synthesis of E- and Z-o-methoxy-substituted 2,3-diphenyl propenoic acids and its methyl esters
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A series of stereoisomeric o-methoxy-substituted 2,3-diphenyl propenoic acids and their methyl esters have been synthesized. The E isomers were prepared by a modified Perkin condensation (substituted benzaldehyde, phenylacetic acid, Et3N/acetic anhydride). The difficult to access Z isomers were obtained conveniently in good yields when the appropriate coumarin derivatives were allowed to react with KOH and CH3I in DMSO.
- Felfoeldi, Karoly,Sutyinszky, Maria,Nagy, Nora,Palinko, Istvan
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p. 1543 - 1553
(2007/10/03)
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