Novel heteroaryl alkylamide derivatives useful as bradykinin receptor modulators
This invention is directed towards novel alkylamide derivatives as bradykinin receptor antagonists useful for the treatment of bradykinin modulated disorders such as pain, inflammation, asthma and allergy. Furthermore, the present invention is directed to novel alkylamide derivatives as bradykinin receptor agonists useful for the treatment of bradykinin modulated disorders such as hypertension and the like.
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Page 36
(2010/02/08)
Synthesis and structure-activity relationships of aroylpyrrole alkylamide bradykinin (B2) antagonists
The synthesis and structure-activity relationships of a novel series of aroylpyrrole alkylamides as potent selective bradykinin B2 receptor antagonists are described. Several members of this series display nanomolar affinity at the B2 receptor and show activity in an animal model of antinociception.
Youngman, Mark A.,Carson, John R.,Lee, Jung S.,Dax, Scott L.,Zhang, Sui-Po,Colburn, Ray W.,Stone, Dennis J.,Codd, Ellen E.,Jetter, Michele C.
p. 1341 - 1344
(2007/10/03)
NOVEL HETEROARYL ALKYLAMIDE DERIVATIVES USEFUL AS BRADYKININ RECEPTOR MODULATORS
This invention is directed towards novel alkylamide derivatives as bradykinin receptor antagonists useful for the treatment of bradykinin modulated disorders such as pain, inflammation, asthma and allergy. Furthermore, the present invention is directed to novel alkylamide derivatives as bradykinin receptor agonists useful for the treatment of bradykinin modulated disorders such as hypertension and the like.
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Page/Page column 82
(2010/02/07)
1,3,6-trihydro-6-aza-3-oxapentalen-2-one derivatives for the treatment of neoplasia
1,3,6-Trihydro-6-Aza-3-Oxapentalen-2-One Derivatives for inhibiting neoplastic conditions.
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(2008/06/13)
Aroyl-substituted pyrroles
The compounds are of the class of 5-aroyl-pyrrole alkanoic acids and corresponding acid derivatives thereof useful as anti-inflammatory agents and as synthetic intermediates.
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(2008/06/13)
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