- TETRAZOLINONE COMPOUND AND APPLICATIONS THEREOF
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Disclosed is a tetrazolinone compound having a high pest control effect and represented by the formula (1): wherein R1, R2, R3, and R11 each represent a halogen atom, a C1-C6 alkyl group, or the like; R4 and R5 each represent a hydrogen atom, a halogen atom, a C1-C3 alkyl group, or the like; R6 represents a C1-C3 alkyl group which may have a halogen atom(s) or the like; R7, R8, and R9 each represent a hydrogen atom, a halogen atom, or the like; R10 represents a C1-C3 alkyl group or the like; R12 represents a C1-C6 alkyl group, a C3-C6 cycloalkyl group, or the like, and R13 represents a C1-C6 alkyl group, a C2-C6 alkenyl group, or the like.
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- Improved alkylation and product stability in phosphotriester formation through quinone methide reactions with dialkyl phosphates
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Investigating reactions of functionalized p-quinone methides continues to advance our design of a reagent being developed for controlled, in situ modification of DNA via phosphodiester alkylation. Previously reported investigations of p-quinone methides derived from catechols allowed for trapping of isolable trialkyl phosphates for characterization and mechanistic information. However, lactone formation with these derivatives required long reaction times, resulting in an unfavorable mixture of trialkyl phosphate and hydrolysis products. To enhance the rate and efficacy of trialkyl phosphate formation and trapping, a phenol derived p-quinone methide has been designed to enforce a conformation favoring lactonization of the dialkyl phosphate alkylated intermediate. The relative rates of phosphodiester alkylation and subsequent trapping of the phosphotriester adduct have been examined by UV and 1H NMR analysis for p-quinone methide precursor 1 and the corresponding control, 1′. The incorporation of a methyl group at the meta-position of 1 (relative to 1′) significantly improves the rate of lactionization to provide a much higher yield of the desired product, lactonized phosphotriester 5. The control reaction with 1′ afforded only a minor amount of the corresponding lactonized trialkyl phosphate 5′.
- Bakke, Brian A.,McIntosh, Matthias C.,Turnbull, Kenneth D.
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p. 4338 - 4345
(2007/10/03)
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- The Photo-Fries Rearrangement of 2,5-Disubstituted Phenyl Acetates
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In a homogenous solution, the photo-Fries rearrangement of 2,5-disubstituted phenyl acetates gives ortho-hydroxyacetophenones as major photoproducts.The ortho/para ratio can be increased by using a highly viscous medium or restricted spaces such as those in zeolites.On the other hand, micellar solutions have little effect.
- Suau, Rafael,Torres, Gregorio,Valpuesta, Maria
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p. 1311 - 1314
(2007/10/02)
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