- Imidazo[1,2-a]pyrazine, Imidazo[1,5-a]quinoxaline and?Pyrazolo[1,5-a]quinoxaline derivatives as IKK1 and IKK2 inhibitors
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The transcription nuclear factor NF-κB plays a pivotal role in chronic and acute inflammatory diseases. Among the several and diverse strategies for inhibiting NF-κB, one of the most effective approach considered by the pharmaceutical industry seems to be
- Patinote, Cindy,Bou Karroum, Nour,Moarbess, Georges,Deleuze-Masquefa, Carine,Hadj-Kaddour, Kamel,Cuq, Pierre,Diab-Assaf, Mona,Kassab, Issam,Bonnet, Pierre-Antoine
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p. 909 - 919
(2017/07/27)
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- Dimethyl Sulfoxide Involved One-Pot Synthesis of Quinoxaline Derivatives
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An efficient, green, and novel method for the synthesis of N-heterocycle-fused quinoxalines is reported herein. Dimethyl sulfoxide was used as both a reactant and a solvent in this reaction. A wide range of products in moderate to excellent yields were obtained, including pyrrolo[1,2-a]quinoxalines, indolo[1,2-a]quinoxalines, 1H-pyrrolo[3,2-c]quinolines, and benzo[4,5]imidazo[1,2-c]quinazolines.
- Xie, Caixia,Zhang, Zeyuan,Li, Danyang,Gong, Jian,Han, Xushuang,Liu, Xuan,Ma, Chen
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p. 3491 - 3499
(2017/04/11)
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- In vitro and in vivo anti-tumoral activities of imidazo[1,2-a]quinoxaline, imidazo[1,5-a]quinoxaline, and pyrazolo[1,5-a]quinoxaline derivatives
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Imidazoquinoxaline and pyrazoloquinoxaline derivatives, analogues of imiquimod, were synthesized, and their in vitro cytotoxic and pharmacodynamic activities were evaluated. In vitro cytotoxicity studies were assessed against melanoma (A375, M4Be, RPMI-75
- Moarbess, Georges,Deleuze-Masquefa, Carine,Bonnard, Vanessa,Gayraud-Paniagua, Stephanie,Vidal, Jean-Remi,Bressolle, Francoise,Pinguet, Frederic,Bonnet, Pierre-Antoine
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p. 6601 - 6610
(2008/12/22)
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- EFFICIENT LIGAND-MEDIATED ULLMANN COUPLING OF ANILINES AND AZOLES
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The present invention provides of method of preparing phenyl-substituted azoles. This method uses an efficient ligand-accelerated Ullmann coupling reaction of anilines with azoles. The coupling products are useful for preparing factor Xa inhibitors.
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- Efficient ligand-mediated ullmann coupling of anilnies and azoles
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The present invention provides of method of preparing phenyl-substituted azoles. This method uses an efficient ligand-accelerated Ullmann coupling reaction of anilines with azoles. The coupling products are useful for preparing factor Xa inhibitors.
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- Novel compounds possessing potent cAMP and cGMP phosphodiesterase inhibitory activity. Synthesis and cardiovascular effects of a series of imidazo[1,2-a]quinoxalinones and imidazo[1,5-a]quinoxalinones and their aza analogues
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A series of novel imidazoquinoxalinones and their aza analogues were prepared by the cyclization of o-amino(1H-imidazol-1-yl)aryls and heteroaryls with carbonyldiimidazole. The compounds were screened for inhibition of Type I and Type IV phosphodiesterase
- Davey,Erhardt,Cantor,Greenberg,Ingebretsen,Wiggins
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p. 2671 - 2677
(2007/10/02)
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