- PYRIDIN-3-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
-
Disclosed are compounds of Formula I, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods for making the compounds and their use in inhibiting HIV integrase and treating those infected with HIV or AIDS.
- -
-
-
- THIAZOLE DERIVATIVES AS STEAROYL COA DESATURASE INHIBITORS
-
The present invention provides thiazole derivatives as Stearoyl CoA Desaturase (SCD) inhibitors. In particular, the compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by Stearoyl CoA Desaturase
- -
-
Page/Page column 34
(2010/04/03)
-
- Development of a scalable synthesis of a nonbasic inhibitor of the serine protease tryptase
-
A chromatography-free process for the synthesis of a bis(benzimidazole)difluoromethane inhibitor of the serine protease tryptase is described. This synthesis features the introduction of the gem-difluoro moiety using the electrophilic fluorinating reagent N-fluoro-bis(phenylsulfonimide) as well as the stepwise introduction of both benzimidazole rings. A protocol for the destruction of reactive, process-related substances produced in the synthesis is also presented.
- Dener, Jeffrey M.,O'Bryan, Colin,Yee, Robert,Shelton, Emma J.,Sperandio, David,Mahajan, Tania,Palmer, James T.,Spencer, Jeffrey R.,Tong, Zhiwei
-
p. 4591 - 4595
(2007/10/03)
-
- ETHER DERIVATIVE
-
The present invention relates to an ether derivative represented by the formula (I), a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof wherein each symbol is as defined in the description, and an ether derivative represented by the formula (III), a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof wherein each symbol is as defined in the description; a pharmaceutical composition containing the ether derivative; and a package containing the pharmaceutical composition and a description of use thereof. A pharmaceutical composition of the present invention, which contains this compound of the present invention has a superior anti-inflammatory and analgesic activity and is useful as various pharmaceutical agents such as an anti-inflammatory agent, an analgesic, a therapeutic agent for inflammatory bowel disease, a therapeutic agent for pollakiuria and/or incontinentia, a therapeutic agent for asthma and the like.
- -
-
Page/Page column 29
(2008/06/13)
-
- MUSCARINIC AGONISTS
-
The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor.
- -
-
-
- HYDROXY-TETRAHYDRO-NAPHTHALENYLUREA DERIVATIVES
-
This invention relates to hydroxy-tetrahydro-naphthalenylurea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The hydroxy-tetrahydro-naphthalenylurea derivatives of the present invention have an excelle
- -
-
-