Scavenger assisted combinatorial process for preparing libraries of amides, carbamates and sulfonamides
This invention relates to a novel solution phase process for the preparation of amide, carbamate, and sulfonamide combinatorial libraries. These libraries have utility for drug discovery and are used to form wellplate components of novel assay kits.
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(2008/06/13)
Rapid microscale synthesis, a new method for lead optimization using robotics and solution phase chemistry: Application to the synthesis and optimization of corticotropin-releasing factor1 receptor antagonists
Process for the preparation of cyclopropylmethyl-n-propylamine
A process for preparing cyclopropylmethyl-n-propylamine from the reaction of cyclopropylmethylamine with propionitrile is described. The reaction takes place in the presence of a hydrogenation catalyst, preferably a mixture of rhodium on carbon and platinum on carbon. The process is particularly useful as it consumes the cyclopropylmethylamine by-product from another scheme for the synthesis of cyclopropylmethyl-n-propylamine.
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(2008/06/13)
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