- Microwave-assisted one step high-throughput synthesis of benzimidazoles
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One-pot synthesis of benzimidazoles from diamines and carboxylic acids was developed under microwave irradiation condition, which provided a practical and efficient method for high-throughput synthesis of this important class of heterocyclic compounds.
- Lin, Shou-Yuan,Isome, Yuko,Stewart, Ethan,Liu, Ji-Feng,Yohannes, Daniel,Yu, Libing
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p. 2883 - 2886
(2007/10/03)
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- Synthesis and evaluation of gastroprotective and antiulcer activity of some 2-substituted-1H-imidazo[4,5-b] pyridines and -1H-benzimidazoles
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Several compounds possessing imidazo[4,5-b]pyridine and benzimidazole structure bearing substituents in position 2 were prepared in order to evaluate an anti-ulcer and gastroprotective activity in rat pylorus ligature, in comparison with omeprazole. Among
- Loriga,Paglietti,Piras,Sparatore,Anania,Piera Demontis,Varoni,Fattaccio
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p. 287 - 304
(2007/10/02)
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- Synthetic Approaches to some Aza-analogues of Benzimidazole N-Oxides. Part 1. The Imidazopyridine Series
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The 3-oxide of 2-p-nitrophenylimidazopyridine (8) may be obtained in good yield by base-induced cyclisation of 2-nitro-3-(p-nitrobenzylamino)pyridine (18).It is also obtained in lower yield, along with p-nitrobenzoic acid and other cleavage products, by the corresponding reactions of bases with the N-ethoxycarbonyl, N-methylsulphonyl, and N-p-tolylsulphonyl derivatives of 2-nitro-3-(p-nitrobenzylamino)pyridine .Cleavage is the main reaction when N-(2-nitro-3-pyridyl)-N-phenacylmethanesulphonamide (17) is treated with bases: phenylglyoxal, or its Schiff base with 3-amino-2-nitropyridine, are possible intermediates in the cleavage process. 3-Nitro-2-(p-nitrobenzylamino)pyridine (31) is similarly cyclised in basic media to give the 1-oxide of 2-p-nitrophenylimidazopyridine (32).
- Andrews, Adrian F.,Smith, David M.,Hodson, Harold F.,Thorogood, Peter B.
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p. 2995 - 3006
(2007/10/02)
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- Heterocyclisation via Selective Elimination: Reaction of 2,3-Diaminopyridine with Acyclic Ketones under Thermal Conditions
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Reactions of 2,3-diaminopyridine and its 5-bromo analogue with three symmetrical and nine unsymmetrical acyclic ketones under thermal conditions have been studied.The reactions have yielded 2-substituted-1H-imidazopyridines by the elimination of one of the C2-substituents from the probable, though unisolated, intermediates 2,2-disubstituted-2,3-dihydro-1H-imidazopyridine derivatives.Elimination of one of the groups in the case of symmetrical ketones and preferentially of benzyl group in the case of benzyl methyl ketone has been observed.All the three alkyl phenyl ketones studied afford 2-phenylimidazopyridine by the selective loss of the alkyl group.Elimination of branched alkyl group has been noticed in the reactions involving methyl t-butyl and methyl i-propyl ketones, while the preferential elimination of methyl group is observed in the case of methyl n-alkyl ketones.Suitable explanations have been offered for the observed selective eliminations.
- Dubey, Pramod Kumar,Ratnam, C. V.
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p. 863 - 865
(2007/10/02)
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