In silico design, synthesis, and screening of novel deoxyhypusine synthase inhibitors targeting HIV-1 replication
The human enzyme deoxyhypusine synthase (DHS) is an important host cell factor that participates in the post-translational hypusine modification of eukaryotic initiation factor 5A (eIF-5A). Hypusine-modified eIF-5A plays a role in a number of diseases, in
Schroeder, Marcus,Kolodzik, Adrian,Pfaff, Katharina,Priyadarshini, Poornima,Krepstakies, Marcel,Hauber, Joachim,Rarey, Matthias,Meier, Chris
p. 940 - 952
(2014/05/20)
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