cas 265989-36-4, tert-butyl 2-((4R,6R)-6-(2-(2-(4- fluorophenyl)-4-(4- hydroxyphenylcarbamoyl)-5-isopropyl-3- phenyl-1H-pyrrol-1-yl)ethyl)-2,2- dimethyl-1,3-dioxan-4-yl)acetate | Articles data ｜lookchem

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265989-36-4

Articles about 265989-36-4Total 2 be found

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Atorvastatin Derived HMG-CoA Reductase Degradation Inducing Compound
The present invention relates to a HMG-CoA reductase degradation-inducing compound and, more specifically, to a bifunctional compound in which atorvastatin and E3 ubiquitin ligase binding moiety are chemically linked as HMG-CoA reductase binding moiety, to a production method thereof, to a HMG-CoA reductase degradation method using the same, and to a pharmaceutical composition for preventing or treating HMG-CoA reductase-related diseases, comprising the same.
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(2020/12/01)

Synthesis of deuterium-labeled atorvastatin and its metabolites for use as internal standards in a LC/MS/MS method developed for quantitation of the drug and its metabolites in human serum
D5-labeled isotopomers of atorvastatin, atorvastatin lactone and its hydroxy metabolites were synthesized as internal standards for use in a LC/MS/MS method developed for the simultaneous quantitative determination of atorvastatin and its hydroxy metabolites in human serum. d5-Atorvastatin and d5-atorvastatin lactone were prepared from d5-aniline whereas their corresponding hydroxy metabolites were synthesized using d5-benzaldehyde.
Chen, Bang-Chi,Sundeen, Joseph E.,Guo, Peng,Bednarz, Mark S.,Hangeland, Jon J.,Ahmed, Syed Z.,Jemal, Mohammed
p. 261 - 270
(2007/10/03)

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Chemical Properties

Boiling Point: 707.815°C at 760 mmHg
Flash Point:381.873°C
Density: 1.184g/cm³
Solubility:Acetone, Chloroform, Dichloromethane, Ethyl Acetate
Vapor Pressure: 0mmHg at 25°C
PKA: 10.00±0.26(Predicted)
PSA: 99.02000
LogP: 9.14760

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