- TRIAZOLE DERIVATIVE OR SALT THEREOF
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[Problem] A compound, which can be used for preventing or treating diseases, in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is concerned, in particular, diabetes, insulin resistance, dementia, schizophrenia and depression, is provided. [Means
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Page/Page column 24
(2011/04/18)
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- Antithrombotic compounds
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Antithrombotic compounds of general formula Exemplary are: (1) 2-(5-carbamimidoyl-2-hydroxy-phenyl)-N-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-ethylamine, (2) N-(5-carbamimidoyl-2-hydroxy-benzyl)-3-methyl-4-(pyrrolidin-1-yl-carbonyl)-benzylamine, and (3) N-(5-carbamimidoyl-2-hydroxy-benzyl)-2,5-dimethyl-4-(pyrrolidin-1-yl-carbonyl)-benzylamine.
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- Fused bicyclic Gly-Asp β-turn mimics with potent affinity for GPIIb-IIIa. Exploration of the arginine isostere
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6-[4-Amidinobenzoyl]amino]-tetralone-2-acetic acid is a potent antagonist of GPIIb-IIIa. Substitution in the meta position of the benzamidine, or replacement with a heteroaryl amidine was tolerated in this series. Use of an acyl-linked 4-alkyl piperidine
- Fisher, Matthew J.,Giese, Ulrich,Harms, Cathy S.,Kinnick, Michael D.,Lindstrom, Terry D.,McCowan, Jefferson R.,Mest, Hans-Juergen,Morin Jr., John M.,Mullaney, Jeffrey T.,Paal, Michael,Rapp, Achim,Ruehter, Gerd,Ruterbories, Ken J.,Sall, Daniel J.,Scarborough, Robert M.,Schotten, Theo,Stenzel, Wolfgang,Towner, Richard D.,Um, Suzane L.,Utterback, Barbara G.,Wyss, Virginia L.,Jakubowski, Joseph A.
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p. 385 - 389
(2007/10/03)
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