The present invention provides novel anticoagulant contrast agents, which comprise an organic scaffolding moiety, an organic anticoagulant moiety, and an imaging moiety. The invention also provides anticoagulant contrast media and methods of visualizing internal structures utilizing the novel anticoagulant contrast agents and anticoagulant contrast media.
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Page/Page column 15-16
(2010/02/15)
Azaindoles: Moderately basic P1 groups for enhancing the selectivity of thrombin inhibitors
Starting from a 2-amino-6-methylpyridine P1 group and following a strategy of enlarging it whilst reducing its polarity, we have developed a series of potent, moderately basic azaindoles which are intrinsically much more selective for thrombin versus tryp
Sanderson, Philip E. J.,Stanton, Matthew G.,Dorsey, Bruce D.,Lyle, Terry A.,McDonough, Colleen,Sanders, William M.,Savage, Kelly L.,Naylor-Olsen, Adel M.,Krueger, Julie A.,Lewis, S. Dale,Lucas, Bobby J.,Lynch, Joseph J.,Yan, Youwei
p. 795 - 798
(2007/10/03)
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