- RE[N(SiMe3)2]3-Catalyzed Guanylation/Cyclization of Amino Acid Esters and Carbodiimides
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The example of rare-earth metal-catalyzed guanylation/cyclization of amino acid esters and carbodiimides is well-established, forming 4(3H)-2-alkylaminoquinazolinones in 65-96% yields. The rare-earth metal amides RE[N(TMS)2]3 (RE = Y, Yb, Nd, Sm, La; TMS = SiMe3) showed high activities, and La[N(TMS)2]3 performed best for a wide scope of the substrates.
- Lu, Chengrong,Gong, Chao,Zhao, Bei,Hu, Lijuan,Yao, Yingming
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p. 1154 - 1159
(2018/02/10)
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- Hydrogen bonding-mediated self-assembly of square and triangular metallocyclophanes
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Intramolecular three-centered hydrogen bonding has been used to induce dipyridyl anthranilamide 5 and diphenylacetylene anthranilamide 11 to adopt rigid straight conformation. Compound 5 reacted with Pd(dppp)(OTf)2 (12a) or Pt(dppp)(OTf)2 (12b) in dichloromethane to afford square metallocyclophanes 13a and 13b in 70% and 40% yield, respectively. In contrast, the reaction of 11 with 12b in dichloromethane gave triangular metallocyclophane 14 in 15% yield.
- Wu, Zong-Quan,Jiang, Xi-Kui,Li, Zhan-Ting
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p. 8067 - 8070
(2007/10/03)
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- 2-Substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity
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9-Trifluoromethyl-paullones with a carbon chain in the 2-position were synthesized by palladium-catalyzed coupling reactions of a 2-iodoprecursor with terminal alkenes or alkynes, respectively. The introduction of a 2-cyanoethyl substituent led to a significant enhancement of CDK1/cyclin B inhibiting property and in vitro antiproliferative activity. (C) 2000 Elsevier Science Ltd. All rights reserved.
- Kunick, Conrad,Schultz, Christiane,Lemcke, Thomas,Zaharevitz, Daniel W.,Gussio, Rick,Jalluri, Ravi K.,Sausville, Edward A.,Leost, Maryse,Meijer, Laurent
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p. 567 - 569
(2007/10/03)
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