A 4,4 '-di-substituted diphenyl ketone compound and its preparation method
The invention provides a 4,4'-dibasic benzophenone compound which has a structure shown in the following formula I. The compound can well inhibit activities of an AP-1 protein and an NDM-1 protein and has the IC50 value of 52.93 plus and minus 11.86muM fo
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(2017/04/06)
Discovery of nonpeptidic small-molecule AP-1 inhibitors: Lead hopping based on a three-dimensional pharmacophore model
We designed and synthesized small-molecule activator protein-1 (AP-1) inhibitors based on a three-dimensional (3D) pharmacophore model that we had previously derived from a cyclic decapeptide exhibiting AP-1 inhibitory activity. New AP-1 inhibitors with a