- SLAP reagents for the photocatalytic synthesis of C3/C5-substituted, N-unprotected selenomorpholines and 1,4-selenazepanes
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Herein, we disclose the first set of unique selenium-containing SLAP (SiLicon Amine Protocol) reagents for the direct synthesis of C3/C5-substituted selenomorpholines and 1,4-selenazepanes fromdiverse (hetero)aldehydes under mild photocatalytic conditions. Enantiomerically pure 1,2-amino alcohol/α-amino acid versions of these heterocycles were also synthesized. Further, we have shown the late-stage modification of certain biologically active agents using the developed seleno-SLAPreagents.
- Zhou, Guan,Deng, Xingwang,Pan, Chenyu,Goh, Eunice Tze Leng,Lakshminarayanan, Rajamani,Srinivasan, Rajavel
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supporting information
p. 12546 - 12549
(2020/11/02)
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- Construction of pH sensitive smart glutathione peroxidase (GPx) mimics based on pH responsive pseudorotaxanes
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Two organoselenium compounds, both of which were modified with two primary amine groups, were designed and synthesized to mimic the catalytic properties of glutathione peroxidase (GPx). It was demonstrated that the catalytic mechanism of the diselenide organoselenium compound (compound 1) was a ping-pong mechanism while that of the selenide organoselenium compound (compound 2) was a sequential mechanism. The pH-controlled switching of the catalytic activities was achieved by controlling the formation and dissociation of the pseudorotaxanes based on the organoselenium compounds and cucurbit[6]uril (CB[6]). Moreover, the switching was reversible at pH between 7 and 9 for compound 1 or between 7 and 10 for compound 2.
- An, Shaojie,Jia, Wenlong,Li, Jiaxi,Ma, Ganghui,Shi, Shan,Wang, Tao,Zhang, Xiaoyin
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p. 3125 - 3134
(2020/05/08)
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- Selenium and sulfur in exchange reactions: A comparative study
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Cysteamine reduces selenocystamine to form hemiselenocystamine and then cystamine. The rate constants are k1 = 1.3 × 105 M-1 s-1; k-1 = 2.6 × 107 M-1 s-1; k2 = 11 M-1 s-1; and k-2 = 1.4 × 103 M-1 s-1, respectively. Rate constants for reactions of cysteine/selenocystine are similar. Reaction rates of selenium as a nucle'phile and as an electrophile are 2-3 and 4 orders of magnitude higher, respectively, than those of sulfur. Sulfides and selenides are comparable as leaving groups.
- Steinmann, Daniel,Nauser, Thomas,Koppenol, Willem H.
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body text
p. 6696 - 6699
(2010/12/24)
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- Selenium containing modifying agents and conjugates
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The invention relates to a modifying agent comprising a water soluble polymer, wherein the water soluble polymer comprises at least one reactive selenium group, said reactive selenium group being capable of reacting with a thiol group thereby forming an -Se-S- bond. Furthermore, the invention relates to a method for producing said modifying agents and their use in the modification of pharmaceutically active agents, e.g. G-CSF. Additionally, the invention concerns conjugates comprising a water-soluble polymer and a pharmaceutically active agent, wherein the water-soluble polymer is linked via a S-Se-bond to agent and a method for their production and their use as medicaments. Finally, the invention concerns a pharmaceutical composition comprising the inventive conjugates.
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- ORGANOTELLURIUM AND SELENIUM-BASED ANTIMICROBIAL ANTIMICROBIAL FORMULATIONS AND ARTICLES
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The invention provides compositions and methods for treating or preventing the spread of infectious disease through topical or cutaneous contact with a formulation or article containing an organotellurium compound, or an inorganic or organic selenium compound, or formulation thereof, capable of generating superoxide radicals in the presence of an agent of infectious disease such as bacteria, viruses, fungi and protozoa.
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Page/Page column 36
(2010/11/28)
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- A facile access to chalcogen and dichalcogen bearing dialkylamines and diols
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A highly practical procedure for the preparation of novel classes of chalcogen bearing diamines [{H2N(CH2)n} 2E] and diols [{HO(CH2)n}2E] (n = 2 or 3 and E = Se or Te) by the reaction of disodiumchalcogenide and haloalkylamines or haloalcohols is presented.
- Milton, Marilyn Daisy,Khan, Shabana,Singh, Jai Deo,Mishra, Vivek,Khandelwal, Bishan Lal
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p. 755 - 758
(2007/10/03)
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