- A head spore for preparation method of the acidic
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The invention discloses a preparation method of ceftezole acid. The preparation method comprises the following steps: in a reaction container, adding cyclohexanone, 7-amino-3-chloromethyl-3-cephalosporin-4-carboxylic acid 2-sulfydryl-1,3,4-thiadiazole shown in a formula (IV),, solid alkali and an alkaline hyamine catalyst, stirring to facilitate the reaction for 1 to 10 hours at the temperature of 20 to 100 DEG C, then adding 1H-1-tetrazole tert-butyl acetate shown in a formula (V), stirring to facilitate the reaction for 1 to 10 hours at the temperature of 20 to 100 DEG C, cooling, and performing posttreatment to obtain the target product ceftezole acid shown in a formula (I). (See the specification).
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Paragraph 0029-0031; 0033-0040
(2018/01/13)
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