- Synthesis, characterization, biological screenings and molecular docking study of Organotin(IV) derivatives of 2,4-dichlorophenoxyacetic acid
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New tri- and diorganotin (IV) derivatives of 2,4-dichlorophenoxyacetic acid with general formula: R3SnL and R2SnL2: {Me3SnL (1), Bu3SnL (2), Me2SnL2 (3), Bu2SnL2 (4) and Oct2SnL2 (5), L = 2,4-dichlorophenoxyacetate} have been synthesized and characterized in solid state by elemental and FT-IR analysis, whereas in solution state by 1H and 13C NMR spectroscopy. Compound 1 was also characterized by single crystal X-ray crystallography. The FT-IR data of compounds 1–5 confirm the bidentate binding mode of ligand with penta and hexa-coordinated arrangements around the Sn(IV) centre in solid state. The value of C–Sn–C angle for complexes 1 and 3 calculated from NMR (1H and 13C) data using Lockart's equation were 114.7° and 114.9°, respectively which falls in the range of 5-coordinated geometry. The DNA binding of synthesized compounds were studied via UV–Vis spectroscopy and viscometry resulting in an intercalative mode of interaction. Molecular docking analysis of the studied compounds also supports the results of the UV–vis and viscometry. Moreover, interaction of the synthesized compounds with a cationic surfactant i.e., cetyltrimethyl ammonium bromide (CTAB) has been studied by conductometric method. Enzyme inhibition activity against α-amylase and α-glucosidase was carried out and compound 3 was found to possess maximum inhibition (88.1% and 91.3%, respectively). The theoretical study also enforce the experimental data for enzyme inhibition of the compound 3 (docking score = ?12.4096) by forming seven hydrogen bonds and two pi-H linkages with the Glu 276, Ala 278, Phe 300, Arg 312, Tyr 313, Asp 349, Asn 412, Phe 430 and Arg 439 residues of the binding pocket of the α-glucosidase. The potency of the compound 3 might be due to the presence of the strong electron withdrawing chloro group. IC50 value of the brine shrimp activity revealed that triorganotin (IV) derivatives (1 and 2) were more toxic than their diorganotin (IV) analogues. Moreover, compound 2 has the MIC values of 12.5 μg/mL and 6.25 μg/mL against S. Aureus and M. Leuteus bacterial strains, respectively.
- Naz, Nida,Sirajuddin, Muhammad,Haider, Ali,Abbas, Syed Mustansar,Ali, Saqib,Wadood, Abdul,Ghufran, Mehreen,Rehman, Gauhar,Mirza, Bushra
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- Complexes of some transition metal ions with selected dichlorophenoxyacetic acid: Thermal, spectral and magnetic properties
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This paper presents the interpretations of data obtained from the investigations of 2,4-dichlorophenoxyacetates of selected lanthanide(III) ions. The compounds of 2,4-dichlorophenoxyacetic acid ion with La(III), Pr(III)–Lu(III) with the formula Ln(C8
- Ferenc, Wies?awa,Cristóv?o, Beata,Sarzyński, Jan,Osypiuk, Dariusz
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- Preparation method of phenoxycarboxylate herbicide
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The invention provides a preparation method of a phenoxycarboxylate herbicide, wherein the preparation method includes the steps: S1, carrying out condensation reaction of phenol or o-cresol with chlorocarboxylic ester under the action of alkaline substances to obtain phenoxycarboxylic ester, wherein chlorocarboxylic ester has the general formula of ClR1COOR, R1 is C1-3 alkylene or alkylidene, R is C1-10 alkyl of or C3-10 cycloalkyl; and S2, under the action of a first catalyst and a second catalyst, carrying out selective chlorination of the phenoxycarboxylic ester with a chlorinating agent to obtain the chlorophenoxycarboxylic ester represented by the formula I, R3 is H, Cl or CH3, the first catalyst is selected from Lewis acid, and the second catalyst is selected from C5-22 thioether, thiazole, isothiazole or thiophene compounds; and S3, mixing chlorophenoxycarboxylic ester with an alkaline compound, and carrying out alkaline hydrolysis to obtain the phenoxycarboxylate herbicide. The preparation method can improve the product quality and production operation environment, and has low quantity of three wastes.
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Paragraph 0103; 0106
(2019/01/08)
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- Preparation method of 2,4-dichlorophenoxyacetic acid and salt thereof
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The invention provides a preparation method of 2,4-dichlorophenoxyacetic acid and a salt thereof, wherein the preparation method includes the following steps: S1) carrying out a reaction of phenol andchloracetic ester under alkaline conditions to obtain phenoxyacetic ester; S2) carrying out selective chlorination reaction of the phenoxyacetic ester with a chlorinating agent under the action of acatalyst A and a catalyst B to obtain 2,4-dichlorophenoxyacetic ester, wherein the catalyst A is Lewis acid, and the catalyst B is C5-22 thioethers, thiazoles, isothiazoles and thiophenes or halogenated derivatives thereof; and S3) carrying out hydrolysis reaction of 2,4-dichlorophenoxyacetic ester under acidic conditions to obtain 2,4-dichlorophenoxyacetic acid; or after 2,4-dichlorophenoxyaceticester is obtained, carrying out an alkaline hydrolysis reaction with an alkaline compound to obtain 2,4-dichlorophenoxyacetate. The production and use of 2,4-dichlorophenol with unpleasant odor are avoided, the production of dioxins is eliminated, the yield of products is improved, and the output of three wastes is greatly reduced.
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Paragraph 0119; 0122
(2019/01/06)
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- Preparation method and production system for 2,4-dichlorophenoxyacetic acid
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The invention provides a preparation method for 2,4-dichlorophenoxyacetic acid. The preparation method comprises the following steps: a) reacting 2,4-dichlorophenol with an alkali to obtain 2,4-dichlorophenolate and reacting haloacetic acid with an alkali so as to obtain haloacetate; B) reacting the 2,4-dichlorophenolate with the haloacetate so as to obtain 2,4-dichlorophenoxyacetate; and C) mixing the 2,4-dichlorophenoxyacetate with acid and carrying out crystallization in a tubular crystallizer so as to obtain 2,4-dichlorophenoxyacetic acid. According to the invention, the 2,4-dichlorophenolate and the haloacetate are separately prepared at first and then subjected to a reaction so as to produce the 2,4-dichlorophenoxyacetate; then the 2,4-dichlorophenoxyacetate is mixed with acid; and finally, crystallization in the tubular crystallizer is carried out. With such a specific continuous crystallization manner, the prepared 2,4-dichlorophenoxyacetic acid is large in particle size and high in purity and yield; and dust is not produced during drying and usage, so environment friendliness is achieved.
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Paragraph 0079-0080; 0082-0088
(2018/09/28)
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- Continuous to produce herbicide 2,4-dichlorophenoxy acetic acid method
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The invention discloses a method for continuously producing herbicide 2,4-dichlorophenoxyacetic acid. According to the method, phenol and chlorine gas are used as raw materials; a continuous chlorination reaction is conducted through a micro-channel reactor to prepare 2,4-dichlorophenol, a condensation reaction is conducted through a tandem condensation reaction kettle to prepare 2,4-dichlorphenoxyacetic acid sodium salt, and then a continuous acidification reaction is conducted through a tandem acidification reaction kettle to prepare the 2,4-dichlorphenoxyacetic acid. Since continuous operation is realized in all the three reactions, the technological process is efficient, environmentally friendly, sustainable and suitable for industrial production; the method has the advantages that energy is saved, consumption is lowered, and emission of pollutants is reduced, and therefore safe and continuous industrial production is achieved.
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Paragraph 0019; 0022; 0023
(2017/03/14)
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- Method for reducing contamination
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Certain exemplary embodiments provide methods for reducing a concentration of a contaminant associated with a medium, which can be any substance or material, such as soil, water, air, and/or fluid. In one exemplary method, the medium is treated with a ferric chelate and an oxidizing agent in amounts effective to oxidize at least a portion of the contaminant.
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Page/Page column
(2014/10/28)
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- Process for preparing solid, free-flowing water-soluble salts of aryloxy-C1 -C4 -alkanecarboxylic acids
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Process for preparing solid, free-flowing water-soluble salts of aryloxy-C1 -C4 -alkanecarboxylic acids by reacting the aryloxy-C1 -C4 -alkanecarboxylic acids with a salt-forming base, the salt formation taking place in the melt in the presence or absence of an entraining agent suitable for the azeotropic removal of water or in solution in the presence of an entraining agent suitable for the azeotropic removal of water and, if appropriate, removing the entraining agent from the reaction mixture during the reaction or subsequently and then isolating the solid salts in a customary manner.
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