- Design, Synthesis and Herbicidal Activities of Tetrahydroisoindoline-1,3-dione Derivatives Containing Alkoxycarbonyl Substituted 2-Benzoxazolinone
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Several different alkoxycarbonyl-substituted 2-benzoxazolinone moieties have been incorporated into a tetrahydroisoindoline-1,3-dione scaffold to provide 25 compounds (1a-1u and 2a-2d). The structures of these compounds were confirmed by 1H and 13C NMR, HRMS and X-ray single-crystal diffraction. Some of these compounds (1g, 1h, 1j, 1k) exhibited excellent herbicidal activities against Abutilon theophrasti, Amaranthus retroflexus and Echinochloa crus-galli at a rate of 375 g AI·ha-1. Among them, compounds 1h and 1j displayed the best post-emergence herbicidal effect against Abutilon theophrasti with ED50 values of 1.8 and 5.3 g AI·ha-1, respectively, which are superior to that of the commercial acifluorfen (44.3 g AI·ha-1). Field trials demonstrated that compound 1h exhibited similar herbicidal activity to a high concentration atrazine, and found to be safer for maize than atrazine. The results of this study therefore show that compound 1h could potentially be used as a post-emergence herbicide for maize fields. Two series of tetrahydroisoindoline-1,3-diones containing an alkoxycarbonyl substituted 2-benzoxazolinone moiety were designed and synthesized. Compound 1h displayed excellent herbicidal effect against Abutilon theophrasti with ED50 values of 1.8 g AI·ha-1, and compound 1h could potentially be used as a new post-emergence herbicide for maize fields.
- Zhang, Hao,Liu, Kechang,Liu, Ruiquan,Li, Qibo,Li, Yongqiang,Wang, Qingmin,Liu, Shangzhong
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p. 749 - 755
(2015/12/05)
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- AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS
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Compounds of the formula (I): or pharmaceutically acceptable salts thereof, wherein A, X, R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for t
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Page/Page column 74
(2013/06/27)
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- 6-Acylamino-5-substituted-benzoxazol-2-one compounds and method for using them
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Disclosed is a 6-acylamino-5-substituted-benzoxazol-2-one compound having the structural formula I: wherein Y is halogen or a substituent group linked to the rest of the compound by a hetero atom, and R′ is a group containing at least 8 carbon atoms. Also
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- 6-Acylamino-5-substituted-benzoxazol-2-one compounds and method for using them
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Disclosed is a 6-acylamino-5-substituted-benzoxazol-2-one compound having the structural formula I: wherein ???Y is halogen or a substituent group linked to the rest of the compound by a hetero atom, and ???R' is a group containing at least 8 carbon atoms
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- Benzothiazol-2-one-3-alkanoic acids and esters and aldose reductase inhibiting compositions thereof
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A pharmaceutical composition comprising certain benzothiazoline alkanoic acid derivatives for the prevention and treatment of various diabetic complications, said derivatives being inhibitors of aldose reductase.
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