- Proton Transfer Tautomerism in the Excited State of Indazole in Acetic Acid: Tautomerization via Double Proton Switching
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It is shown that the S1 state of 1H-indazole in acetic acid undergoes double proton transfer along the hydrogen bonds in the indazole-acetic acid complex.The proton transfer converts 1H-indazole into 2H-indazole.The rate of proton transfer is estimated to be 2.7x109 s1- from transient fluorescence measurements.
- Noda, Masayo,Hirota, Noboru,Sumitani, Minoru,Yoshihara, Keitaro
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Read Online
- BTK INHIBITOR
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Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).
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Paragraph 0958-0959
(2017/11/16)
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- Consecutive condensation, C-N and N-N bond formations: A copper-catalyzed one-pot three-component synthesis of 2 H -indazole
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2H-Indazoles are synthesized using copper-catalyzed, one-pot, three-component reactions of 2-bromobenzaldehydes, primary amines, and sodium azide. A copper catalyst plays the key role in the formation of C-N and N-N bonds. This method has a broad substrate scope with a high tolerance for a variety of functional groups.
- Kumar, Manian Rajesh,Park, Ahbyeol,Park, Namjin,Lee, Sunwoo
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supporting information; experimental part
p. 3542 - 3545
(2011/09/12)
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- Radical scavenging by N-aminoazaaromatics
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N-Aminoazaaromatics were found to react with nitric oxide in the presence of oxygen to afford deaminated products in high yields. The reaction proceeded almost instantaneously in various solvents including water, and one to two equivalent of NO was consumed depending upon the amount of oxygen coexisted, and 1 equivalent of N2O was released in the reaction. In addition, N-aminoazoles were deaminated by potassium superoxide to give parent azoles in good yields. Two equivalents of superoxide was consumed, and about half equivalents of both nitrite and nitrate ion were released. The results demonstrated that N-aminoazoles have ability to protect the biological system against the oxidation promoted by radicals such as nitrogen oxides and superoxide. Copyright (C) 2000 Elsevier Science Ltd.
- Itoh, Takashi,Miyazaki, Michiko,Maeta, Hiromi,Matsuya, Yuji,Nagata, Kazuhiro,Ohsawa, Akio
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p. 1983 - 1989
(2007/10/03)
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- 2-substituted indazoles from electrogenerated ortho-nitrosobenzylamines
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An electrochemical methodology for an efficient access to ortho- nitrosobenzylamines has been developed. These products cyclize intramolecularly producing the desired 2-substituted indazoles in high yields. The electrochemical procedure overcomes limitations of previous chemical methods.
- Frontana-Uribe, Bernardo A.,Moinet, Claude
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p. 3197 - 3206
(2007/10/03)
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- REACTIONS OF SODIUM SALTS OF TOSYLHYDRAZONE COMPOUNDS WITH SILVER CHROMATE. FORMATION OF INDAZOLE, PYRAZOLE, AND BENZONITRILE DERIVATIVES.
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Tropone tosylhydrazone sodium salt was allowed to react with silver chromate to give 2-tosyl-2H-indazole. The reaction is thought to proceed through the cyclization of the hydrazyl radical intermediate. Under the same conditions, sodium salts of m-nitrobenzaldehyde tosylhydrazone (5), benzylideneacetone tosylhydrazone derivatives (7a and 7b), and beta -ionone tosylhydrazone (9) reacted to yield m-nitrobenzonitrile from 5 and pyrazole derivatives from 7a, b, and 9, respectively. m-Nitrobenzonitrile is formed by homolytic fission of nitrogen-nitrogen bond of 5. Formation of the pyrazole derivatives can be explained by intramolecular 1,3-dipolar additions of the corresponding diazo intermediates.
- Saito,Toda,Mukai
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p. 1567 - 1569
(2007/10/02)
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