- Amide exchange reaction: A simple and efficient CuO catalyst for diacetamide synthesis
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A highly copper-catalysed amide exchange reaction of hexamethylenediamine (HDA) with CH3CN and H2O for the synthesis of hexamethylenebisacetamide (HMBA) without an organic solvent or gas protection was developed. 100% HDA conversion and >99% HMBA selectivity was obtained. X-ray diffraction, scanning emission microscopy, and temperature-programmed reduction of hydrogen were used to characterize the structural properties of the catalyst. The reaction mechanism was also investigated.
- Li, Qinghe,Wang, Peixue,Deng, Youquan
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p. 40890 - 40894
(2016/05/19)
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- Synthesis of GN8 derivatives and evaluation of their antiprion activity in TSE-infected cells
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A series of GN8 derivatives were synthesized from various diamines, carboxylic acid derivatives, and nitrogen nucleophiles, and their antiprion activity was tested in TSE-infected mouse neuronal cells. We found that two ethylenediamine units, hydrophobic substituents on the nitrogen atoms, and the diphenylmethane scaffold were essential structural features responsible for the activity. Seven derivatives bearing substituents at the benzylic position exhibited an improved antiprion activity with the IC50 values of 0.51-0.83 μM. Conformational analysis of model compounds suggested that the introduction of the substituent at the benzylic position restricted the conformational variability of the diphenylmethane unit.
- Kimura, Tsutomu,Hosokawa-Muto, Junji,Kamatari, Yuji O.,Kuwata, Kazuo
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supporting information; experimental part
p. 1502 - 1507
(2011/04/23)
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- Synthetic and mechanistic aspects of acid-catalyzed disproportionation of dialkyl diarylmethyl ethers: A combined experimental and theoretical study
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The disproportionation reactions of various dialkyl diarylmethyl ethers have been carried out in the presence of a catalytic amount (10 mol-%) of o-benzenedisulfonimide as a Bronsted acid catalyst; the reaction conditions were mild, and the yields of the diarylmethane target products were good. The catalyst was easily recovered and purified, ready to be used in further reactions. The theoretical study confirmed that the reaction proceeds in two steps: The formation of a carbocation from the protonated ether followed by hydride transfer. Although the hydride transfer is the rate-determining step, it is the stability of the carbocation that determines the reaction rate and therefore the yields.
- Barbero, Margherita,Bazzi, Stefano,Cadamuro, Silvano,Dughera, Stefano,Ghigo, Giovanni
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experimental part
p. 4346 - 4351
(2011/02/24)
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- N-Acylsulphonamides as acyl transferring agents
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N-acylsulphonamides 2a and 2b are found to transfer acyl groups to amino compounds under thermal activation giving the products in moderate to good yields.Acyl transfer is also possible to reactive phenols such as 1-naphthol and resorcinol under ZnCl2 catalysis to produce C-acylated products.
- Mashraqui, Sabir H.,Nirantar, Swati S.,Biswas, Maloyesh M.
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p. 1102 - 1104
(2007/10/03)
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- Acrylic acid heterocyclic amides, fungicidal compositions and use
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Compounds of the formula STR1 wherein A, B, R1, X and Q are substituents of various types, and acid addition salts thereof. The compounds are useful as fungicides.
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