- 4-Hydroxy-2-quinolones. 37. Simple synthesis of 1-R-2-oxo-3,4-dihydroxyquinolines
-
3-Amino-1-R-2-oxo-4-hydroxyquinolines easily undergo acid hydrolysis with formation of the corresponding 1-R-2-oxo-3,4-dihydroxyquinolines. 1998 Plenum Publishing Corporation.
- Ukrainets,Taran,Sidorenko,Gorokhova
-
p. 1334 - 1336
(2007/10/03)
-
- Glycine receptor antagonist pharmacophore
-
Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer''s disease, amyotrophic lateral sclerosis, Huntington''s disease and Down''s syndrome, treating or preventing the adverse consequences of the hyperactivity of the excitatory amino acids, as well as treating anxiety, chronic pain, convulsions and inducing anesthesia are disclosed by administering to an animal in need of such treatment a compound which has high binding to the glycine receptor.
- -
-
-
- Ylides of Heterocycles, VIII. Reactions of Iodonium-Ylides with Acids
-
The reaction of various organic and inorganic acids (HX) with iodonium ylides 2 leads to nucleophilic substitution of the iodobenzene substituent by the anion X(-) to yield the heterocycles 5.Some of them are hydrolyzed to the hydroxy compounds 3 or reduced to the starting compounds 1 under the reaction conditions.Reaction of the iodonium ylide 2b with monomethyl sulfate gives the salt 9, which with bases undergoes nucleophilic substitution to compounds 8 and 10-12, respectively, or is converted to 2b again. - Keywords: 3-Acetoxy-4-hydroxy-2-quinolones; 2-Oxoquinoline-4-olates; 3-Substituted 4-hydroxy-2-quinolones
- Pongratz, Erik,Kappe, Thomas
-
p. 231 - 242
(2007/10/02)
-