Design, synthesis and structure-activity relationships of novel strychnine-insensitive glycine receptor ligands
The in vitro activities of 3-hydroxy-imidazolidin-4-one derivatives demonstrated very restricted structure-activity relationships at the strychnine-insensitive glycine site of the NMDA receptor. The most active compound (3a) was completely unsubstituted and exhibited affinity and efficacy similar to that of D-cycloserine, the prototypical partial agonist at this site.
Cordi,Lacoste,Audinot,Millan
p. 1409 - 1414
(2007/10/03)
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