The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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Paragraph 1738-1739
(2014/06/25)
Selective inhibitors of EG5 motors and methods of use
Embodiments of the present invention comprises a compound of formula I or its enantiomer, diastereomer, stereoisomer or its pharmaceutically acceptable salt, methods of use and methods of synthesis.
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Page/Page column 36
(2013/03/26)
Synthesis and characterization of tritylthioethanamine derivatives with potent KSP inhibitory activity
Assembly of a bipolar mitotic spindle requires the action of class 5 kinesins, and inhibition or depletion of this motor results in mitotic arrest and apoptosis. S-Trityl-l-cysteine is an allosteric inhibitor of vertebrate Kinesin Spindle Protein (KSP) th
Rodriguez, Delany,Ramesh, Chinnasamy,Henson, Lauren H.,Wilmeth, Lori,Bryant, Bj K.,Kadavakollu, Samuel,Hirsch, Rebecca,Montoya, Johnelle,Howell, Porsha R.,George, Jon M.,Alexander, David,Johnson, Dennis L.,Arterburn, Jeffrey B.,Shuster, Charles B.
experimental part
p. 5446 - 5453
(2011/10/19)
Aminosulf(ox)ides as Ligands for Iridium(I)-Catalyzed Asymmetric Transfer Hydrogenation
A new class of efficient catalysts was developed for the asymmetric transfer hydrogenation of unsymmetrical ketones. A series of chiral N,S-chelates (6-22) was synthesized to serve as ligands in the iridium(I)-catalyzed reduction of ketones. Both formic a
Petra, Danielle G. I.,Kamer, Paul C. J.,Spek, Anthony L.,Schoemaker, Hans E.,Van Leeuwen, Piet W. N. M.
p. 3010 - 3017
(2007/10/03)
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