cas 273404-37-8, (S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide | Articles data ｜lookchem

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273404-37-8

Articles about 273404-37-8Total 7 be found

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Caspase inhibitors
A compound, or a pharmaceutically acceptable salt or ester thereof, of formula I: X—W wherein X is a caspase-selective structure and W has the structure of —NH—CH(Y)(Z) wherein Y is
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Page/Page column 29

(2016/12/16)

Prodrug of an ice inhibitor
This invention describes an ICE inhibitor prodrug (I) having good bioavailability. Compound I is useful for treating IL-1 mediated diseases such as rheumatoid arthritis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, inflammatory periton
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(2016/11/24)

A highly potent and selective caspase 1 inhibitor that utilizes a key 3-cyanopropanoic acid moiety
Herein, we examine the potential of a nitrile-containing propionic acid moiety as an electrophile for covalent attack by the active-site cysteine residue of caspase 1. The syntheses of several cyanopropanate-containing small molecules based on the optimiz
Boxer, Matthew B.,Quinn, Amy M.,Shen, Min,Jadhav, Ajit,Leister, William,Simeonov, Anton,Auld, Douglas S.,Thomas, Craig J.
scheme or table
p. 730 - 738
(2011/02/21)

Development of a novel Pd-catalyzed N-acyl vinylogous carbamate synthesis for the key intermediate of ICE inhibitor VX-765
(Chemical Equation Presented) A novel Pd-catalyzed coupling of Cbz-protected proline amide with 4-bromo-5-ethoxyfuran-2(5H)-one was developed for the synthesis of the P1-P2 unit (5) of VX-765. The process afforded quantitative coupling in the presence of water, providing a 1:1 mixture of 5 and its ethoxy epimer epi-5. Compound 5 was isolated as a single diastereomer via fractional crystallization, which was stereoselectively converted to 17 via hydrogenation, and subsequently transformed to VX-765. Nine examples of the Pd coupling are presented with yields ranging from 76-98%.
Tanoury, Gerald J.,Chen, Minzhang,Dong, Yong,Forslund, Raymond E.,Magdziak, Derek
p. 185 - 188
(2008/09/18)

PROCESSES AND INTERMEDIATES
The invention relates to processes and compounds useful for producing modified aspartic acid derivatives, such as aspartic acid aldehyde moieties. Aspartic acid derivatives are useful for preparing caspase inhibitors and/or prodrugs thereof.
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Page/Page column 77-78

(2008/06/13)

Process and intermediates for making substituted aspartic acid acetals
Disclosed herein is a method for making compounds that are useful as caspase inhibitor prodrugs of formula I: wherein R1 is an optionally substituted group selected from an aliphatic group, aralkyl group, heterocyclylalkyl group or aryl group,
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(2008/06/13)

Prodrug of an ice inhibitor
This invention describes an ICE inhibitor prodrug (I) having good bioavailability. Compound I is useful for treating IL-1 mediated diseases such as rheumatoid arthritis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, inflammatory periton
-
(2008/06/13)

More Articles about upstream products of 273404-37-8

Chemical Properties

Boiling Point: 779.0±60.0 °C(Predicted)
Density: 1.32
Solubility:Soluble in DMSO (>25 mg/ml)
Storage Temp.:-20°C
PKA: 12.60±0.40(Predicted)
PSA: 147.04000
LogP: 3.78620

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