Widely applicable Pd-catalyzed trans-selective monoalkylation of unactivated 1,1-dichloro-1-alkenes and Pd-catalyzed second substitution for the selective synthesis of E or Z trisubstituted alkenes
(Chemical Equation Presented) Double substitution: The first selective and widely applicable method for a step-wise alkylation of 1,1-dichloro-1-alkenes involving a cross-coupling double substitution using Pd-catalysis has been developed. This method provides an efficient and highly selective route for the synthesis of E or Z trisubstituted alkenes. dpephos = bis(o- diphenylphosphanylphenylether).
Direct preparation of vinyl halides from the corresponding ketones and acetyl halides
Vinyl chlorides and bromides are obtained in good yield from the corresponding ketones and acetyl halides in the presence of trifluoroacetic or trifluoromethanesulfonic acid. The Z isomer is selectively formed.
Moughamir, Khadija,Mezgueldi, Bouchra,Atmani, Aziz,Mestdagh, Helene,Rolando, Christian