- SUBSTITUTED HETEROCYCLIC COMPOUNDS
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Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.
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- Effect of Carbonyl Substitutents on the Barrier to Rotation in N-Ethyl-N-methylamides
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The barriers to rotation about the C(O)-N bond for 13 α-alkyl- and α-halo-substituted N-theyl-N-methylamides were determined by 1H NMR spectroscopy at coalescence temperature.Plots of Gibbs free energy (ΔG0) and Gibbs energy of activation (ΔG(e
- Bonacorso, Helio G.,Caro, Miguel S. B.,Zanatta, Nilo,Martins, Marcos A. P.
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p. 451 - 454
(2007/10/02)
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