cas 27471-40-5, 1-(4-FLUORO-PHENYL)-PIPERIDIN-2-ONE | Articles data ｜lookchem

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27471-40-5

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Discovery of novel c-met inhibitors bearing a 3-carboxyl piperidin-2-one scaffold
A series of compounds containing a novel 3-carboxypiperidin-2-one scaffold based on the lead structure BMS-777607 were designed, synthesized and evaluated for their c-Met kinase inhibition and cytotoxicity against MKN45 cancer cell lines. The results indi
Zhang, Wei,Ai, Jing,Shi, Dakuo,Peng, Xia,Ji, Yinchun,Liu, Jian,Geng, Meiyu,Li, Yingxia
p. 2655 - 2673
(2014/03/21)

Discovery of novel type II c-Met inhibitors based on BMS-777607
Twenty-two new analogs based on the structure of BMS-777607 were designed, synthesized, and evaluated to determine their biological activities. Compounds bearing a cyclic sulfonamide or α-chloropiperidone scaffold exhibited good activity, which may provid
Zhang, Wei,Ai, Jing,Shi, Dakuo,Peng, Xia,Ji, Yinchun,Liu, Jian,Geng, Meiyu,Li, Yingxia
p. 254 - 266
(2014/05/20)

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Chemical Properties

Boiling Point: 384.6±25.0 °C(Predicted)
Density: 1.189±0.06 g/cm3(Predicted)
PKA: 0.61±0.20(Predicted)
PSA: 20.31000
LogP: 2.40760

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