PREPARATION OF 3,5-DIOXO HEXANOATE ESTER IN TWO STEPS
The invention discloses a method for the preparation of tert-butyl 6-chloro-3,5- dioxohexanoate from Meldrum's acid derivative and its use for the preparation of tert-butyl (4R,6S)-(6-hydroxymethyl-2,2-dimethyl-1,3-dioxan-4-yl)acetate(BHA), Rosuvastatin and Atorvastatin.
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Page/Page column 24
(2012/10/18)
Highly regio- and enantioselective reduction of 3,5-dioxocarboxylates
Only the keto group in position C-5 is reduced in the enzymatic reduction of 3,5-dioxocarboxylates by the alcohol dehydrogenase of Lactobacillusbrevis (LBADH; see scheme). The strategy of nature for manipulating β-keto metabolites inspired the development of a chemoenzymatic approach to virtually enantiopure 3,5-dihydroxycarboxylate building blocks. The crucial enzymatic step can be performed on an attractively large scale.
Wolberg, Michael,Hummel, Werner,Wandrey, Christian,Mueller, Michael
p. 4306 - 4308
(2007/10/03)
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