- ANTIBIOTIC AMMONIUM COMPOUNDS AND METHODS FOR THE TREATMENT OF BACTERIAL INFECTIONS
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The present disclosure provides ammonium compounds, e.g., compounds according to Formula I as set forth herein, which are useful as antimicrobial agents. Methods for the treatment of bacterial infections and associated conditions, e.g., gastrointestinal conditions, are also described, as well as methods for altering the microbiome of subjects such as humans.
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- Preparation method of octylonium bromide
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The invention belongs to the field of drug synthesis, and provides a preparation method of octylonium bromide. The preparation method of the octylonium bromide comprises the following steps: synthesizing methyl o-octyloxybenzoate from methyl salicylate as
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- Highly Ordered Nanoporous Films from Supramolecular Diblock Copolymers with Hydrogen-Bonding Junctions
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We designed efficient precursors that combine complementary associative groups with exceptional binding affinities and thiocarbonylthio moieties enabling precise RAFT polymerization. Well defined PS and PMMA supramolecular polymers with molecular weights up to 30 kg mol?1are synthesized and shown to form highly stable supramolecular diblock copolymers (BCPs) when mixed, in non-polar solvents or in the bulk. Hierarchical self-assembly of such supramolecular BCPs by thermal annealing affords morphologies with excellent lateral order, comparable to features expected from covalent diblock copolymer analogues. Simple washing of the resulting materials with protic solvents disrupts the supramolecular association and selectively dissolves one polymer, affording a straightforward process for preparing well-ordered nanoporous materials without resorting to crosslinking or invasive chemical degradations.
- Montarnal, Damien,Delbosc, Nicolas,Chamignon, Cécile,Virolleaud, Marie-Alice,Luo, Yingdong,Hawker, Craig J.,Drockenmuller, Eric,Bernard, Julien
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p. 11117 - 11121
(2016/07/06)
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- A branched, hydrogen-bonded heterodimer: a novel system for achieving high stability and specificity
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Presented is a description of the design, synthesis, and characterization of a novel, branched, six hydrogen-bonded heterodimer termed 'trident'. Two branched oligoamide molecules, 1 and 2, with complementary hydrogen-bonding sequences 3(AD) and 3(DA), re
- Bialecki, Jason B.,Yuan, Li-Hua,Gong, Bing
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p. 5460 - 5469
(2008/01/07)
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- Cyclic hexapeptide compounds
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Compounds of the formula STR1 wherein R1 is hydrogen or hydroxyl; R2 is hydrogen; hydroxyl or methyl, R3 is hydrogen or hydroxyl; R4 is C5 -C23 alkyl, C5 -C23 alkenyl, aryl or substituted aryl; R5 is --CH2 OH, --CH(CH3)OH, --CH(CH2 CONH2)OH; R6 is --CH2 OH or --CH(CH3)OH; R is --CH2 OH or --CH(CH3)OH; provided that when R4 is --(CH2)8 CH(CH3)CH2 CH(CH3)C2 H5, R5 is --CH2 OH or --CH(CH3)OH. The compounds are useful as antimicrobial agents, especially as antifungal agents.
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- Alkylphenyl 3-cyano or fluoro-4-alkyloxybenzoates and mesomorphic mixtures thereof
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An organic compound having a high negative dielectric anisotropy is capable, by mixing with a nematic liquid crystal, of improving the dynamic scattering effect of the liquid crystal. The organic compounds have the formula: STR1 in which R is either a flu
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