- Synthesis of Novel Disaccharides Based on Glycosyltransferases: β1,4Galactosyltransferase
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β1,4Galactosyltransferase and β-galactosidase have been investigated with regard to their acceptor specificity and used in the synthesis of galactosides using 5-thioglucose, deoxyazaglucose, glucal, modified N-acetylglucosamine and glucose derivatives as acceptors.
- Wong, Chi-Huey,Krach, Thomas,Narvor, Christine Gautheron-Le,Ichikawa, Yoshitaka,Look, Gary C.,et al.
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- Synthesis of Glycosylated 1-Deoxynojirimycins Starting from Natural and Synthetic Disaccharides
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Iminosugars are an important class of natural products and have been subject to extensive studies in organic synthesis, bioorganic chemistry and medicinal chemistry, yet only a limited number of these studies are on glycosylated iminosugars. Here, a general route of synthesis is presented towards glycosylated 1-deoxynojirimycin derivatives based on the oxidation–reductive amination protocol that in the past has also been shown to be a versatile route towards 1-deoxynojirimycin. The strategy can be applied on commercial disaccharides, as shown in four examples, as well as on disaccharides that are not commercially available and are synthesized for this purpose, as shown by a fifth example.
- Liu, Bing,van Mechelen, Jeanine,van den Berg, Richard J. B. H. N.,van den Nieuwendijk, Adrianus M. C. H.,Aerts, Johannes M. F. G.,van der Marel, Gijsbert A.,Codée, Jeroen D. C.,Overkleeft, Herman S.
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p. 118 - 129
(2019/01/04)
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- A highly efficient TEMPO mediated oxidation of sugar primary alcohols into uronic acids using 1-chloro-1,2-benziodoxol-3(1H)-one at room temperature
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Oxidation of various sugar primary alcohols into corresponding uronic acids was demonstrated using 1-chloro-1,2-benziodoxol-3(1H)-one and TEMPO. The reaction proceeds at room temperature in good to excellent yields. Primary alcohols get oxidized selective
- Tiwari, Varsha,Badavath, Vishnu Nayak,Singh, Adesh Kumar,Kandasamy, Jeyakumar
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p. 2511 - 2514
(2018/05/29)
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- Indirect and direct approaches in the synthesis of a new mono-6-O-benzyl methylated γ-cyclodextrin as chiral selector for enantioselective gas chromatography
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6I-O-Benzyl-2I-VIII, 3I-VIII, 6II-VIII-tricosa-O-methyl-γ-cyclodextrin was synthesized using indirect and direct approaches. The first indirect strategy consists of a multi-step sequence including the ring opening of the permethylated α-cyclodextrin, elongation of the chain with a 6-O-benzyl methylated disaccharide derivative, and macrocyclization. The direct method deals with a selective mono-6-O-TBDMS protection, permethylation, deprotection, and benzylation sequence of γ-cyclodextrin. The results clearly show the higher efficiency of the direct approach but demonstrate the feasibility of the insertion of a modified maltose derivative (indirect method). The new mono-6-O-modified methylated γ-cyclodextrin was used as a selector for the preparation of the new chiral stationary phase. Preliminary enantioselective gas chromatography applications are also reported.
- Chaise, Thomas,Cardinael, Pascal,Tisse, Severine,Combret, Jean-Claude,Bouillon, Jean-Philippe
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p. 348 - 357
(2008/09/19)
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- An efficient glycosylation reaction for the synthesis of asialo GM2 analogues
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We investigated the coupling reaction of glycosyl donors N-trichloroethoxycarbonyl-galactosamine-O-trichloroacetimidate (2a) and N-p-nitrobenzyloxycarbonyl-galactosamine-O-trichloroacetimidate (2b) with the 4′-OH of lactose derivatives (3a-d) to synthesiz
- Sun, Bin,Pukin, Aliaksei V.,Visser, Gerben M.,Zuilhof, Han
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p. 7371 - 7374
(2007/10/03)
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- A facile protocol for direct conversion of unprotected sugars into phenyl 4,6-O-benzylidene-per-O-acetylated-1,2-trans-thioglycosides
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A short and practical methodology for conversion of unprotected D-glucose, maltose, cellobiose and lactose into the corresponding phenyl 4,6-O-benzylidine-per-O-acetylated-1,2-trans-thioglycosides is described. The protocol is based on the execution of five reaction steps (bromoacetylation, thiophenolysis under phase transfer catalysis conditions, deacetylation, benzylidenation and acetylation) in one continuous procedure and provides a fast access to the title compounds as pure crystalline products without chromatographic purification.
- Larsen, Kim,Olsen, Carl Erik,Motawia, Mohammed Saddik
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p. 199 - 202
(2007/10/03)
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- Chemical synthesis of cyclodextrins by using intramolecular glycosylation
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An efficient synthesis of cyclodextrins (CDs) by using the intramolecular glycosylation is demonstrated. α-CD, an α(1→4)linked hexaglucoside, was prepared via a block condensation of three maltose units. A modified key maltose intermediate as a precursor to both glycosyl donor and acceptor components was prepared in 6 steps starting from maltose. All the glycosylation for chain elongation and cyclization of saccharides was carried out after tethering the donor to the acceptor by the phthaloyl bridge to give the desired saccharides in good yields with complete α-selectivity. δ-CD composed of 9 glucose units was synthesized by the same manner from three maltotriose units.
- Wakao, Masahiro,Fukase, Koichi,Kusumoto, Shoichi
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p. 8182 - 8190
(2007/10/03)
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- New phenyl 6,4'-substituted-1-thio-β-maltosides, building blocks for the synthesis of linear and branched malto-oligosaccharides
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An efficient strategy to synthesize a number of new phenylthio-maltoside derivatives in yields from 55 to 95% is described. These derivatives can be used as suitable building blocks for stepwise synthesis of starch derived malto-oligosaccharides.
- Motawia,Larsen,Olsen,Moller
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p. 1547 - 1556
(2007/10/03)
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- Direct synthesis of pseudo-disaccharides by rearrangement of unsaturated disaccharides
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The series of unsaturated disaccharides 10-14 undergo stereoselective reductive rearrangement with TIBAL (triisobutylaluminium) to afford (1→4) and (1→6) ether-linked pseudo-disaccharides 2-9.
- Pearce, Alan James,Sollogoub, Matthieu,Mallet, Jean-Maurice,Sinay, Pierre
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p. 2103 - 2117
(2007/10/03)
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- Novel molecular clamp method for anomeric stereocontrol of glycosylation
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Stereocontrolled glycosylation is described by using a molecular clamp, which binds a glycosyl donor to an acceptor and controls their spatial arrangement. An α(1→4) glycosidic linkage was formed in a good yield with high selectivity by the use of a phthaloyl bridge bound to both 6-positions of a glycosyl donor and an acceptor. β-Selective glycosylation was effected by the use of a silyl bridge attached to the same 6-positions of the same glycosyl donor and acceptor. Application of this method to the synthesis of a maltotetraose derivative is also described.
- Wakao, Masahiro,Fukase, Koichi,Kusumoto, Shoichi
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p. 1911 - 1914
(2007/10/03)
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- Synthesis of a di- and a trisaccharide related to the antigen from Klebsiella type 16
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Using methyl triflate as promoter, methyl O-(2,3,4,6-tetra-O-benzyl-α-D-glucopyranosyl)-(1 → 4)-(methyl 2,3-di-O-benzoyl-β-D-glucopyranosyluronate) and methyl O-(2,3,4,6-tetra-O-benzyl-β-D-galactopyranosyl)-(1 → 4)-O-(2,3,6-tri-O-benzyl-α-D-glucopyranosyl
- Choudhury, Ambar Kumar,Roy, Nirmolendu
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p. 3937 - 3945
(2007/10/03)
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- Synthesis of ganglioside G(M3) and G(M4) analogs having mimics of ceramide moieties and their binding activities with influenza virus A
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Ganglioside G(M4) (1) and G(M3) (2) analogs, which contain mimics of the ceramide moieties of gangliosides, were synthesized. The syntheses of 1 and 2 feature stereoselective glycosylation of methyl (phenyl 5-acetamido-4,7,8,9- tetra-O-acetyl-3,5-dideoxy-2-thio-β-D-galacto-2-nonulopyranosid)onate (10) as the sialosyl donor with suitably protected galactose and lactose acceptors catalyzed by N-bromosuccinimide (NBS), iodine, and tetrabutylammonium trifluoromethanesulfonate (TBAOTf) as the glycosyl promoter in acetonitrile under kinetically controlled conditions. Compound 2 exhibited binding activity towards influenza virus A.
- Nagao,Nekado,Ikeda,Achiwa
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p. 1536 - 1542
(2007/10/03)
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- Dibutylstannylene acetals: Useful intermediates for the regioselective sulfation of glycosides
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Sulfated mono- and disaccharides were synthesised by a novel sulfation method via regioselective activation of the saccharides to their dibutyltin stannylene acetals, followed by treatment with sulfur trioxide-trimethylamine. This methodology was applied
- Guilbert,Davis,Pearce,Aplin,Flitsch
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p. 2163 - 2178
(2007/10/02)
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- Chemical synthesis and NMR spectra of a protected branched-tetrasaccharide thioglycoside, a useful intermediate for the synthesis of branched oligosaccharides
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Acid catalyzed thiophenolysis of per-O-acetylated 1,6-anhydromaltose (3) gave phenyl 2,3-di-O-acetyl-4-O-(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-1-thio-β-D-gluxopyranoside (4) in quantitative yield.Phenyl 4-O-α-D-glucopyranosyl-1-thio-β-D-glucopyranos
- Motawia, Mohammed Saddik,Olsen, Carl Erik,Moeller, Birger Lindberg,Marcussen, Jan
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