MODIFICATION OF TRYPTOPHAN RESIDUES DURING ACIDOLYSIS OF 4-METHOXY-2,3,6-TRIMETHYLBENZENESULFONYL GROUPS. EFFECTS OF SCAVENGERS
The formation of by-product 1 of tryptophan during the cleavage of Mtr from arginine can be minimized by addition of 1,2-ethanedithiol.Under too drastic conditions, however, a dithioketal product 2 is formed.
SYNTHESIS OF FRAGMENTS OF THE ADRENOCORTICOTROPIC HORMONE (ACTH1-10, ACTH11-24, AND ACTH1-24) WITH THE USE OF A CHROMOGENIC C-TERMINAL PROTECTIVE GROUP LABILE TO ALKALI
A method for the fast synthesis of fragments of adrenocorticotropin (regions 1-10, 11-24, and 1-24 of the amino acid sequence of ACTH) has been developed which allows us to produce preparative quantities of these peptides.A colored 2-(4-phenylazobenzylsulfonyl)ethyl C-terminal protective group, removable by bases, was used in the synthesis.
Kalashnikov, V. V.,Polyakova, I. M.
p. 971 - 974
(2007/10/02)
APPLICATION OF THE NG-(2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULPHONYL) DERIVATIVE OF FMOC-ARGININE TO PEPTIDE SYNTHESIS
The trifluoroacetic acid labile pentamethylchromanylsulphonyl protecting group for the guanidino group of arginine has been used in conjunction with the base-labile Fmoc Nα protecting group for the synthesis of arginine-containing peptides.
Green, J.,Ogunjobi, O. M.,Ramage, R.,Stewart, A. S. J.
p. 4341 - 4344
(2007/10/02)
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