Discovery of phosphonic diamide prodrugs and their use for the oral delivery of a series of fructose 1,6-bisphosphatase inhibitors
Like most phosphonic acids, the recently discovered potent and selective thiazole phosphonic acid inhibitors of fructose 1,6-bisphosphatase (FBPase) exhibited low oral bioavailability (OBAV) and therefore required a prodrug to achieve oral efficacy. Synth
Dang, Qun,Kasibhatla, Srinivas Rao,Jiang, Tao,Fan, Kevin,Liu, Yan,Taplin, Frank,Schulz, William,Cashion, Daniel K.,Reddy, K. Raja,Van Poelje, Paul D.,Fujitaki, James M.,Potter, Scott C.,Erion, Mark D.
experimental part
p. 4331 - 4339
(2009/05/30)
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