- Mirabamides E-H, HIV-inhibitory depsipeptides from the sponge Stelletta clavosa
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Four new depsipeptides, mirabamides E-H (1-4), and the known depsipeptide mirabamide C (5) have been isolated from the sponge Stelletta clavosa, collected from the Torres Strait. The planar structures were determined on the basis of extensive 1D and 2D NMR and HRESIMS. The absolute configurations were established by the advanced Marfey's method, NMR, and GC-MS. The four new compounds all showed strong inhibition of HIV-1 in a neutralization assay with IC50 values of 121, 62, 68, and 41 nM, respectively.
- Lu, Zhenyu,Van Wagoner, Ryan M.,Harper, Mary Kay,Baker, Heather L.,Hooper, John N. A.,Bewley, Carole A.,Ireland, Chris M.
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experimental part
p. 185 - 193
(2011/04/26)
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- Halogenated fatty acid amides and cyclic depsipeptides from an eastern Caribbean collection of the cyanobacterium Lyngbya majuscula
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A lipophilic extract of an eastern Caribbean collection of Lyngbya majuscula yielded two new halogenated fatty acid amides, grenadamides B (1) and C (2), and two new depsipeptides, itralamides A (3) and B (4), along with the known compounds hectochlorin a
- Jimenez, Jorge I.,Vansach, Tifanie,Yoshida, Wesley Y.,Sakamoto, Bryan,Poerzgen, Peter,Horgen, F. David
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supporting information; experimental part
p. 1573 - 1578
(2010/03/31)
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