Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.
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(2008/06/13)
Syntheses and lipophilicities of tetraarylborate ions substituted with many trifluoromethyl groups
Syntheses were investigated using various tetraarylborate ions with a large number of trifluoromethyl groups: tetrakisborate; tetrakisborate; tetrakisborate; and tetrakisborate ions.The preparation of Grignard reagents and the subsequent reaction with boron trifluoride etherate are importantsteps for a higher yield and easier isolation of the product.Sodium- and tetramethylammonium salts of these borate ions are soluble in halocarbon solvents such as dichloromethane, chloroform and 1,2-dibromotetrafluoroethane.
Intermediates for preparing hipolipemic agents and method of lowering the blood lipid level in mammals with said agents
Intermediates for preparing benzylthio-, benzylsulfinyl-, and benzylsylfonyl-benzoic acids, and method of lowering the blood lipid level in mammals employing said acids.
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(2008/06/13)
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