- Synthetic method of bumetanide
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The invention provides a synthetic method of bumetanide. The synthetic method comprises the following specific steps: 3-amino-4-phenoxy-5- sulfamoylbenzoic acid and n-butyl alcohol are added to a reactor and stirred at room temperature, a Lewis acid catalyst is added, a reaction is performed for 2-10 h, and pure bumetanide is obtained through post-processing after the reaction. The method is short in reaction step, short in reaction time and high in efficiency, the product yield and purity are higher, reaction conditions are mild, equipment corrosion is avoided, and industrial production is facilitated.
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Paragraph 0015; 0016; 0017; 0018; 0019
(2017/07/20)
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- SUBSTITUTED ANTHRANILIC ACIDS
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Disclosed herein are substituted anthranilic acids, pharmaceutically acceptable salts and prodrugs thereof, the chemical synthesis thereof, and medical use of such compounds for the treatment and/or management of hypertension, edema associated with congestive heart failure, hepatic disease, renal disease including nephrotic syndrome, or clearance of toxic substances from the body.
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Page/Page column 29
(2008/12/04)
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- 2,3-dihydrobenzofuran-5-sulfonamide derivatives useful as antihypertensive diuretic agents
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Highly effective diuretic antihypertensives, i.e., 2,3-dihydrobenzofuran-5-sulfonamide derivatives which is classified to loop diuretics with less adverse side-effects and can be administered orally at a daily dosage of 0.5-200 mg or parenterally of 0.01-50 mg.
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- Process for the manufacture of substituted amino-benzoic acid derivatives
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3-Alkylamino-5-sulfamyl benzoic acid derivatives are prepared by reducing 3-acylamino-5-sulfamyl-benzoic acid derivatives by means of boron hydrides or complex boron hydrides in the presence of Lewis acids.
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