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In this study, we aimed to investigate the relationship between the cytotoxic and dielectric properties of newly synthesized 2,2,4,4-tetra(4′-oxy-substituted-chalcone)-6,6-diphenylcyclotriphosphazene derivatives (3–10). Firstly, 2,2,4,4-tetrachloro-6,6-di

We investigated the cytotoxic effects of the newly synthesized cyclotriphosphazene derivatives on A2780 (ovarian), PC-3 and LNCaP (prostate) cancer cell lines. 4′-hydroxy-supstituted-chalcone compounds (2–8) were reacted with diphenyl-cyclotriphosphazene (DPP) in the presence of acetone/K2CO3 in order to obtain novel cyclotriphosphazene compounds (DPP 2–8). The structures of DPP 2–8 were characterized by MALDI-TOF mass spectrometry, FT-IR, elemental analysis, 1H, 13C-APT, and 31P NMR measurements. The thermal properties of all phosphazene compounds have been studied after synthesis and characterization procedure. The cytotoxic effects of DPP 2–8 were examined primarily by applying the MTT method based on the measurement of mitochondrial activity. In this regard, several phosphazene compounds have shown high chemotherapeutic effect at low dose (p 50 values (p 0.05). The compounds DPP 2–8 possess cytotoxic activity against PC-3 and LNCaP cells (especially compounds DPP-4 and DPP-5, p 0.05).

Reaction of gem-diphenyltetrafluorophosphazene, [1,1-(C6H5)2]P3N3F4 (1) with LiO(CH2)3OLi resulted in the formation of four products, spiro-{3,3-[O(CH2)sub

Through aminolysis with methylamine, phenylation with benzene in the presence of aluminum chloride, and a combination of both, a series of derivatives of trimeric phosphonitrilic chloride has been made. H1 nuclear magnetic resonance spectra were obtained for these compounds and used to determine both their positional and cis-trans configurations. The structural analysis is based on consideration of the number of chemical environments and the values of the coupling constants.