cas 284686-15-3, 2-Amino Nevirapine | Articles data ｜lookchem

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284686-15-3

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Synthesis of five nevirapine metabolites
Nevirapine (1) is a non-nucleoside reverse transcriptase inhibitor marketed for HIV treatment by Boehringer Ingelheim as Viramune since 1996. In vitro studies of nevirapine biotransformation using human liver microsomes demonstrated the formation of five major metabolites. This paper describes the syntheses of these metabolites.
Grozinger, Karl G.,Byrne, Denis P.,Nummy, Laurence J.,Ridges, Michael D.,Salvagno, Annette
p. 229 - 239
(2007/10/03)

5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
Disclosed are novel 5,11-dihydro-6H-dipyrido[3,2-b; 2',3'-e][1,4]diazepines. These are useful in the prevention or treatment of HIV infection.
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(2008/06/13)

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Chemical Properties

Boiling Point: 480.8±45.0 °C(Predicted)
Density: 1.411±0.06 g/cm3(Predicted)
Solubility:DMF (Very Slightly, Heated), DMSO (Very Slightly, Heated)
Storage Temp.:-20°C Freezer, Under inert atmosphere
PKA: 11.67±0.20(Predicted)
PSA: 90.58000
LogP: 2.40290

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