- N-Hydroxymethylation of 3-Aryl-2-cyanoprop-2-enethioamides
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Abstract: Hydroxymethylation of (E)-3-aryl-2-cyanoprop-2-enethioamides with an aqueous alcoholic solution of formaldehyde has afforded (E)-3-aryl-N-(hydroxymethyl)-2-cyanoprop-2-enethioamides. The predictive analysis of the biological activity of the obtained compounds in silico has been carried out.
- Chigorina, E. A.,Dotsenko, V. V.,Krivokolysko, S. G.
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p. 1411 - 1417
(2020/09/21)
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- Studies on enamines and azaenamines: 2-Oxoarylhydrazonals as C-1 nucleophiles
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2-Oxoarylhydrazonals 1a,b react with aldehydes; piperidine; morpholine and benzotriazole to yield the corresponding Mannich bases 2a,f, and 4. Formaldehyde reacts with 1a,b to yield the hydroxymethylarylhyrazons 5a,b together with bisarylhydrazones 6. The hydroxymethyl derivatives 5a are converted to arylhydrazonal 7 upon oxidation in refluxing nitrobenzene. The reaction of aldehydes and malononitrile with 1a,b in ethanolic solution in presence of chitozan as heterogeneous catalyst afforded 6-amino-1,4-dihydropyridazins 14a,b. The Japan Institute of Heterocyclic Chemistry.
- Al-Mousawi, Saleh M.,Moustafa, Moustafa Sherief,Elnagdi, Mohamed Hilmy
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experimental part
p. 2201 - 2211
(2011/04/16)
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