- QUINOXALINONES AND DIHYDROQUINOXALINONES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS
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Quinoxalinones and dihydroquinoxalinones having inhibitory activity on RSV replication and having the formula (I) including addition salts, and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.
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Page/Page column 25; 26
(2014/08/07)
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- Amination of 4-Nitro- and 4-Cyanopyridazines by Liquid Ammonia/Potassium Permanganate
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4-Nitro-3-R1-6-R2-pyridazines (1) (a, R1 = R2 =2-pyridyl; b, R1 = H, R2 = phenyl; c, R1 = H, R2 = p-methoxyphenyl; d, R1 = R2 = H) are aminated by liquid ammonia/potassium permanganate to the corresponding 5-amino-4-nitropyridazines 3a-d.The 4-cyano-3-R1-6-R2-pyridazines 4a,b are only aminated in the presence of potassium amide in liquid ammonia/potassium permanganate to give the 5-amino-4-cyanopyridazines 6a,b.The 5-amino-4-nitropyridazines 3a,b,d are converted to the 4,5-diaminopyridazines 7a,b,d by reduction over a Pd/C catalyst.Reaction of7b with glyoxal leads to 5-phenylpyrazinopyridazine (8b).
- Marcelis, Antonius T. M.,Tondijs, Hanna,Plas, Henk C. van der
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p. 831 - 833
(2007/10/02)
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