- Sakurai reaction of 3,3-bis(silyl) silyl enol ethers with acetals involving selective desilylation of the geminal bis(silane). Concise synthesis of nematocidal oxylipid
-
3,3-Bis(silyl) silyl enol ethers have been shown to exhibit predominantly Sakurai reactivity, rather than Mukaiyama aldol reactivity, in their Lewis acid promoted reactions with acetals. Starting from a geminal bis(silyl) moiety consisting of two differen
- Li, Linjie,Ye, Xincui,Wu, Ya,Gao, Lu,Song, Zhenlei,Yin, Zhiping,Xu, Yongjin
-
p. 1068 - 1071
(2013/04/10)
-
- β-hydroxy-γ-lactones as chiral building blocks for the enantioselective synthesis of marine natural products
-
The enantioselective synthesis of trans-(+)-laurediol, (2S,3S,5R)-5-[(1R)-1-hydroxy-9-decenyl]-2-pentyltetrahydro-3-furanol, and (2S,3S,5S)-5-[(1S)-1-hydroxy-9-decenyl]-2-pentyltetrahydro-3-furanol are described. In addition, a formal synthesis of trans-(-)-kumausyne is also developed. All the synthetic procedures have in common the use of enantiomerically enriched β-hydroxy-γ-lactones, easily available by Sharpless asymmetric dihydroxylation (AD) from the suitable β,γ-unsaturated ester. The use of Katsuki - Sharpless asymmetric epoxidation (AE) as an additional enantioselective reaction provides cyclic compounds of high enantiomeric purity.
- Garcia,Martin,Martin
-
p. 1420 - 1428
(2007/10/03)
-
- Enantiocontrolled synthesis of C-19 tetrahydrofurans isolated from the marine alga Notheia anomala
-
The stereocontrolled synthesis of (2S,3S,5R)-5-[(1R)-1-hydroxy-9- decenyl]-2-pentyltetrahydro-3-furanol and (2S,3S,5S)-5-[(1S)-1-hydroxy-9- decenyl]-2-pentyltetrahydro-3-furanol, both isolated from the brown alga Notheia anomala has been achieved. The req
- García, Celina,Soler, Marcos A.,Martín, Víctor S.
-
p. 4127 - 4130
(2007/10/03)
-